why does fibrinogen tend to be higher in tumour patient????

Answer 1

Dr. YayBob has a great answer above - - as usual.
The point of your question, other than pure curiosity, is that some patients with malignancies tend to be hypercoagulable - they get into difficulty with widespread clotting. We see this with certain adenocarcinomas - especially those involving the gastro-intestinal tract such as gastric or pancreatic. As if these people did not have enough trouble to contend with, they also are at risk for blood clots.
But I suspect you already knew this since you had the knowledge to ask the question.

There's a terrific review of Trousseau's syndrome in the September 15, 2007 issue of the journal "Blood".
(See excerpt below and also the site of you want to read the whole article.) 'Tis very strange that Dr. Armand Trousseau
died of the very syndrome he first described - - stomach cancer with blood clotting.

"Trousseau's syndrome is well known to clinicians, partly because Armand Trousseau not only described it in 1865
but also diagnosed the syndrome on himself 2 years later, succumbing shortly thereafter to a gastric cancer. The association between cancer and excessive blood coagulation remains well-recognized, forming the basis of many reviews, monographs, symposia, and international conferences. Most of these begin by mentioning Trousseau and his eponymous syndrome. Trousseau made an astute clinical observation, noting that some patients who presented with unexpected, unusual, or migratory thromboses later manifested a visceral malignancy. This description was refined and extended over the years, culminating in a classic review by Sack et al,4 in which Trousseau's syndrome was reported as being frequently associated with chronic disseminated intravascular coagulopathy, platelet-rich microthrombi, microangiopathic hemolytic anemia, verrucous endocarditis, and thromboembolic problems related to these processes. In more recent times, many patients are diagnosed with Trousseau's syndrome even if they do not manifest these classic features, and the definition has included those presenting primarily with uncomplicated lower limb deep venous thrombosis. The term is sometimes even applied to patients who already have an advanced malignancy and then develop some form of thrombosis. Although similar mechanisms may be operating, such advanced cases often have other reasons for a thrombotic tendency, such as immobility, dehydration, mechanical compression of veins, infectious processes, chemotherapy, and so forth."

Answer 2

It's an acute phase reactant, meaning its presence is summoned in the inflammatory reactions early and in large amounts. Fibrinogen is a clotting protein. Tumors tend to be antigenic and induce a systemic inflammatory response that does many things, including raising acute phase reactants like fibrinogen in the body's war against the mutant clone.

From http://www.medterms.com/script/main/art.asp?articlekey=30780

"Acute-phase protein: Any protein whose plasma concentration increases (or decreases) by 25% or more during certain inflammatory disorders. The acute-phase proteins include C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen, and alpha 1-acid glycoprotein."

and from http://info.cancerresearchuk.org/news/archive/newsarchive/2007/march/18096490

"Inflammatory response may boost cancer spread
THURSDAY 22 MARCH 2007 - The inflammatory response to tumour growth - which should help protect the body - may actually boost the spread of some cancers, researchers have said."

Answer 3

please tell me you're NOT a medical doctor clarifying a clinical question on yahoo answers.