what is the effect of cholchicine on mitosis?

Question

preferably brief description required

Answer 1

cholchicine breaks down microtubules which pull apart the chromsomes and other cell parts in mitosis. So it stops the cells from completing mitosis. If I recall correctly it causes arrest in metaphase, but I wouldn't swear to that last bit.

Answer 2

Colchicine Mitosis

Answer 3

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RE:
what is the effect of cholchicine on mitosis?
preferably brief description required

Answer 4

Colchicine is an agent useful in the treatment of gout. Its use has fallen in recent years. This article discusses the effectiveness of colchicine and suggests that it could be used more often.

History
Alkaloid of the crocus (meadow saffron).
Used to treat gout in 1763.
Introduced to North American and used by Benjamin Franklin.
Clinical Pharmacology:
The main anti-inflammatory mechanism of colchicine1 is via inhibition of granulocyte migration into the inflamed area. This inhibits mitosis thus affecting cells with high turnover (GI tract, marrow). Symptoms of a fatal overdose are similar to those of severe radiation poisoning.

Peak oral absorption is in 1-2 hours, hence the acute repeat dosing interval. Colchicine has a long duration (approx. 9 days) in leukocytes allowing for wide maintenance dose intervals (daily or twice/week).

The adverse effects on the GI tract are largely due to overzealous dosing, with the unrealistic goal of rapid, 100% pain relief. This historic dose recommendation (6-7 mg total dose) is unrealistic and dangerous.

A study in the Australia-New Zealand Journal of Medicine showed that in a controlled study of colchicine for the treatment of acute gout, two-thirds of colchicine-treated patients improved after 48 hours, but only one-third of the patients receiving placebo demonstrated similar improvement. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.2

Comparison of colchicine's effectiveness vs more commonly used anti-inflammatories is depicted in attached Fig. 13. Indomethacin works faster than Colchicine in the treatment of acute gouty arthritis, but that after 2 days the effect is about the same. Adverse effects of NSAIDs however are not trivial, especially in the aging population:

silent ulcers
exacerbation of hypertension and reversal of antihypertensive drug effect
exacerbation of heart failure and pulmonary edema plus blockade of beneficial effect of furosemide on the kidney.
confusion
It might then, be appropriate to treat acute gout pain with an NSAID and colchicine for the first day and then drop the NSAID, while continuing the colchicine. Another alternative would be to use colchicine from the beginning but combine it with an analgesic (e.g. Acetaminophen + codeine) for the first day. It is also apparent that the dose of colchicine needed for effective therapy is much lower than what is currently recommended. Use 1.2 mg initially and then 0.6 mg bid. This should reduce or eliminate the GI side effects. Cost is not an issue since colchicine 0.6 mg and generic indomethacin 25 mg are each about 8 cents.

Answer 5

Here is what you do to your Husband for making you worry when you have pregnant brain... Give him that legendary opportunity to taste your breast milk. He'll think he's won the lottery and will boast to all of his friends. Then, in a month, as he's about to have intercourse with you for the first time since giving birth, or when the guys are over, simply explain that he drank traces of love cheese and liked it, and you suspect he likes the taste man drippins. Let's see if he is still in the mood after that.

Answer 6

Colchicine effectively functions as a "mitotic poison" or spindle poison.