Why does Provigil stop working after 2-3 weeks. If it worked for me; what is similar that I might try?

Question

I've suffered depression for over a decade. It was seasonal when living up north; but is now steady year round; but not as severe living in the South. I've tried every SSRI, Wellbutrin, Adderall, you name it and none pull me completely out without making me miserable in another area such as poor sex drive, weight gain, emotional blunting, etc. Provigil was the ONLY medicine that made me feel completely normal; it was a godsend; but after two weeks it began to stop working almost completely even after dose increase. This question is aimed at chemists or persons very familiar with actions of meds on the brain. The provigil allowed me to wake up almost instantly (rather than sleeping 14 hours a day), I had a sex drive, I thought clearly, no side effects, a pure miracle but short lived. Definitely not a placebo affect, it was far too distinct. What action does Provigil have on the brain, and is there any other drug, legal or not, that would be similar? My life is worthless.

Answer 1

Call your pharmacist. Or any pharmacist that's open now. They are SO smart, and can answer that question better than many doctors. The pharmacist won't be too busy at this hour and will be happy to really explain things to you.

I just googled Provigil, and it is supposedly like Adrefinil. There's a lot of information. I googled Provigil+other madications similar.

I still say, call a pharmacist! Good luck to you. As a fellow sufferer of depression and anxiety, I really feel your pain. I think Klonopin is a wonder drug. Ask the pharmacist about Klonopin. Your life is not worthless, you just need to keep searching for the right help. I have faith that you will find it. Don't give up. I'll say a prayer for you tonight. Good luck, my friend. :)