ADVAIR DISKUS Questions?

Question

Someone told me that ADVAIR DISKUS can/could
cause heart problems & that it can/could
cause someones heart to stop.
(1.) Is that true???
(2.) Why or Why not???
(3.) Why would she say such a thing that isn't true???

The person told me it made her have heart problems.
But if that was true I wouldn't think that
the FDA would approve of the drug& doctors wouldn't
prescribe it.
I'm so worried about taking it now.
I'm going to see if my psycharist will help me
take it tonight just in case I have a serious side
effect of the medince & just in case I have a allergic
reaction to the medince since my whole family
doesn't take things seriously.
(3.)Should I have my psycharist help me take it tonight???
(4.) Why or Why not???
(5.) Why does she think Advair Diskus caused her heart problems???

Answer 1

Yes it's a dangerous drug, this article will answer all your questions:

ADVAIR DISKUS 250/50 with an incidence of 1% to 3% and that occurred at a greater incidence than with placebo were:

Cardiovascular

Syncope

Drug Interaction, Overdose, and Trauma

Postoperative complications

Ear, Nose, and Throat

Ear, nose, and throat infections; ear signs and symptoms; laryngitis; nasal congestion/blockage; nasal sinus disorders; pharyngitis/throat infection.

Endocrine and Metabolic

Hypothyroidism

Eye

Dry eyes, eye infections.

Gastrointestinal

Constipation, gastrointestinal signs and symptoms, oral lesions.

Hepatobiliary Tract and Pancreas Abnormal liver function tests.

Lower Respiratory

Breathing disorders, lower respiratory signs and symptoms.

Non-Site Specific

Bacterial infections, candidiasis unspecified site, edema and swelling, nonspecific conditions, viral infections.

Psychiatry

Situational disorders.
Observed During Clinical Practice

In addition to adverse events reported from clinical trials, the following events have been identified during worldwide use of any formulation of ADVAIR, fluticasone propionate, and/or salmeterol regardless of indication. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These events have been chosen for inclusion due to either their seriousness, frequency of reporting, or causal connection to ADVAIR DISKUS, fluticasone propionate, and/or salmeterol or a combination of these factors.

In extensive US and worldwide postmarketing experience with salmeterol, a component of ADVAIR DISKUS, serious exacerbations of asthma, including some that have been fatal, have been reported. In most cases, these have occurred in patients with severe asthma and/or in some patients in whom asthma has been acutely deteriorating (see WARNINGS), but they have also occurred in a few patients with less severe asthma. It was not possible from these reports to determine whether salmeterol contributed to these events.

Cardiovascular

Arrhythmias (including atrial fibrillation, extrasystoles, supraventricular tachycardia), ventricular tachycardia.

Ear, Nose, and Throat

Aphonia, earache, facial and oropharyngeal edema, paranasal sinus pain, throat soreness.

Endocrine and Metabolic

Cushing syndrome, Cushingoid features, growth velocity reduction in children/adolescents, hypercorticism, hyperglycemia, weight gain, osteoporosis.

Eye

Cataracts, glaucoma.

Gastrointestinal

Abdominal pain, dyspepsia, xerostomia.

Musculoskeletal

Back pain, cramps, muscle spasm, myositis.

Neurology

Paresthesia, restlessness.

Non-Site Specific

Immediate and delayed hypersensitivity reaction (including very rare anaphylactic reaction), pallor. Very rare anaphylactic reaction in patients with severe milk protein allergy.

Psychiatry

Agitation, aggression, depression.

Respiratory

Chest congestion; chest tightness; dyspnea; immediate bronchospasm; influenza; paradoxical bronchospasm; tracheitis; wheezing; reports of upper respiratory symptoms of laryngeal spasm, irritation, or swelling such as stridor or choking.

Skin

Contact dermatitis, contusions, ecchymoses, photodermatitis.

Urogenital

Dysmenorrhea, irregular menstrual cycle, pelvic inflammatory disease, vaginal candidiasis, vaginitis, vulvovaginitis.

Eosinophilic Conditions

In rare cases, patients on inhaled fluticasone propionate, a component of ADVAIR DISKUS, may present with systemic eosinophilic conditions, with some patients presenting with clinical features of vasculitis consistent with Churg-Strauss syndrome, a condition that is often treated with systemic corticosteroid therapy. These events usually, but not always, have been associated with the reduction and/or withdrawal of oral corticosteroid therapy following the introduction of fluticasone propionate. Cases of serious eosinophilic conditions have also been reported with other inhaled corticosteroids in this clinical setting. While ADVAIR DISKUS should not be used for transferring patients from systemic corticosteroid therapy, physicians should be alert to eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, and/or neuropathy presenting in their patients. A causal relationship between fluticasone propionate and these underlying conditions has not been established (see PRECAUTIONS: General: Eosinophilic Conditions ).
DRUG INTERACTIONS

ADVAIR DISKUS has been used concomitantly with other drugs, including short-acting beta2-agonists, methylxanthines, and intranasal corticosteroids, commonly used in patients with asthma or COPD, without adverse drug reactions. No formal drug interaction studies have been performed with ADVAIR DISKUS.
Not approved by FDA.

Answer 2

I don't know what the "doctor''s specialty is, but he's off base on Advair. Virtually all the pulmonologists (lung doctors) I know still prescribe it. If it was as bad as many claim, then a lot more patients would have a lot more heart problems.

Answer 3

Is advair diskus going to come out in a generic form any time soon ?

Answer 4

How does Advair Diskus work for you?

Advair Diskus is a preparation of Fluticasone propionate and salmeterol xinafoate, which fulfill both the requirement needed in the treatment of asthma and CPODs. The exact mechanism of action of this therapy is not known. But it assumed that when the patient suffering from these diseases start to take this combination therapy, Fluticasone propionate starts working on the constricted parts and salmeterol xinafoate starts working for the inflammation of the bronchioles starting from the trachea to the terminal bronchioles. Thus the symptoms come under control and helps keep maintain a comfortable breathing. Advair Diskus works by activation of the beta adrenergic receptors of the bronchial smooth muscles of the lung which further cause the activation of the cyclase adenylate monophosphate. The activated cyclase adenylate monophosphate stimulates the activation of the protein Kinase-A which pause the phosphorylation of myosin. When the myosin phosphorylation stops, it lowers the intracellular ionic calcium level and improves the airway smooth muscle relaxation.
What are the indications of Advair Diskus?

Advair Diskus is used in the patients who are suffering from asthma and chronic pulmonary obstructive diseases (CPODs) of lung like chronic bronchitis, emphysema or both.
Advair Diskus in asthma:

This drug is used to control the symptoms of asthma like shortness of breath and wheezing sound in both the adult and children between the ages of 4-6 years.

Advair Diskus in CPODs:

It is a prescription drug used for the treatment of some chronic diseases like emphysema, Chronic bronchitis etc. It keeps the symptoms of COPD under control for several days.

Always use this drug according to the instructions of your physician because this combination therapy is mainly created for the treatment of chronic respiratory problems.
Doses of Advair Diskus:

It is available in three strengths such as:

Advair Diskus 100/50(flutacasone propionate 100mcg and salmeterol 50mcg inhalation powder)
Advair Diskus 250/50(Flutacasone propionate 250mcg and salmeterol 540mcg inhalation powder)
Advair Diskus 500/50(Flutacasone propionate 500mcg and salmeterol 50mcg inhalation powder)

Always read carefully the leaflet that comes with the Advair Diskus before taking the medication. But the consultation with your doctor should always be the first priority to take the therapy. Because the health care provider only will decide whether you are fit for the therapy or not.
What are the contra-indications of Advair Diskus?

This combination therapy has the following contra-indications:

It is not used in the patient who are allergic to protein milk. If you are sure, ask for your doctor.
If you are allergic to Flutacasone, salmeterol or any other components of the preparation.
Other conditions: This preparation is not used in a patient who has the following problems,

Cardiac problems

High blood pressure
Thyroid problem
Osteoporosis
Low immunity
Eye problems like glaucoma or cataract.
If you have viral, bacterial or fungal infections.
Children who are exposed to measles or chicken pox
Patient who are allergic to any components of the preparations.
Pregnancy and lactation period.

What is the drug Interaction of Advair Diskus?

Always inform your doctor if you are taking any over-the-counter medicines, vitamins, herbal supplements because these drugs can interact with Advair Diskus and cause serious complications.
Always avoid anti-fungal or anti-HIV medicines if you are going to use this medication.
Do not forget to inform your physician if you are taking anti-hypertensives, anti-convulsants.
Never use this medication if you are allergic to any of the components of the preparation.

What should you do if you miss dose?

By chance, if you miss a dose, skip the missed dose. Take the next dose according to the schedule. You should never take the 2 doses together.
What should you do if you take an overdose?

If you take Advai Diskus in extra amount, contact with your doctor or the emergency department of your nearest hospital if you catch the symptoms like shortness of breath, increased heart rat or shakiness.
What are the side effects of Advair Diskus?

Some of the side effects of this therapy are mentioned below:

Fungal infection: Advair Diskus may cause fungal infection in your mouth. Always rinse your mouth with water after using this inhalation to reduce the chance of infections.
Pneumonia: Patient suffering from CPOD are more prone to develop pneumonia during using this therapy and catch the following symptoms:
Increased mucus production.
Fever
Cough
Breathing problem
Poor immunity
Adrenal insufficiency:
Feeling tired
Weakness
Nausea and vomitng
Hypotension

Allergic Reaction:

Always consult with your doctor if you catch the symptoms like:

Edema or swelling of your face.
Rashes on the skin.
Difficulty in breathin.

Cardiac effect:

High blood pressure
Cardiac arrhythmias
Chest pain
Bone problem

Central nervous system effect:

Anxiety
Tremors
Nervousness

Eye problem:

Eye pain
Glaucoma

Steps of using Advair Diskus:

The following steps should be used if you are using this inhaler:

Step1:Open the advair Diskus and hold it with the left hand. Then place your thumb of the right hand on the grip and push the thumb grip away from you till the mouthpiece is seen and placed into place.
Step2: Slide the lever until a click sound is heard. Hold the Diskus in the proper position keeping the mouthpiece towards you. After that you should slide the lever away from mouthpiece till you hear the click sound. Then the counter will count down the number by 1 and now you can use the Diskus.
Step3: Step3 is inhalation. Before you inhale, breath out deep when you hold the Diskus away from the mouth. You should not breath into the mouthpiece. Then put the mouthpiece to your lips and breath in and out quickly. While doing this, do not breath through the nose. Then take the mouthpiece away from the your mouth and hold your breath for 10 minutes. Diskus deliver the medication in powder form.
Step4: Closing of Diskus.

Place your thumb on the thumb grip and slide the lever back till the click sound is heard and the mouthpiece is not visible.
Precautions and warnings of Advair Diskus:

You should take the following precautions while you are taking this medication:

Always Inform your doctor if you are taking any LABA medicines.
Do not stop using this medication without consulting with a health care provider because it may cause some complications.
Always take advice from your doctor if you develop any side effects mentioned above.

Always keep a rescue inhaler if you are using this medication. Because Advair Diskus may not give sudden relief.
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