A child aged two years presents with anemia. Peripheral smear shows target cells and hypochromic/microcytic?

Question

what test you would like to do?

Answer 1

Electrophoresis.

Thanks, Kasey for your explanation.

Answer 2

The most common cause of anemia in children is iron deficiency which results in the microcytic/hypochromic cell types on the peripheral blood smear.

Useful tests can include serum iron, TIBC (total iron binding capacity), ferritin, reticulocyte count, hemoglobin electropharesis and a lead level.

However, a simple trial of supplemental dietary iron would be the most sensible and cost effective approach.

So the answer I wouldn't necessarily do any further testing until an iron trial is attempted unless the anemia is severe.

Answer 3

Loving Heart is right... Target cells present with hypochromia and microcytosis are often found in hemoglobinopathies --- like Thalassemia. Hemoglobin electrophoresis is a blood test to check for the presence of variant types of hemoglobins in your blood. Additionally, it would be helpful to know the individual's ethnic background - thalassemia is mostly found in those of Mediterrean descent.