Do statin drugs really lower COENZYME Q10???

Question

I read that Canadian doctors that prescibe statins had to suggest that the patient suppliment their coq10 needs. And that coq10 is used in Japan for congestive heart failure.

Answer 1

I hope you will get help from this article:

Statins Inhibit Coenzyme Q10 Synthesis

Since coenzyme Q10 (CoQ10) and cholesterol are both synthesized from the same substance, mevalonate, statin drugs (Lipitor, Zocor, etc) also inhibit the body's synthesis of coenzyme Q10. This is not a "side effect," of statins, but a direct, inherent function of the drugs.

In fact, the use of statins can decrease the body's synthesis of coenzyme Q10 by as much as 40%!1

Functions of Coenzyme Q10

Coenzyme Q10 is a fat-soluble antioxidant that is found in virtually all cell membranes, hence its alternative name "ubiquinone." The antioxidant activity of vitamin E requires the CoQ10 to be available, to which vitamin E will pass on the unpaired electron (free radical) that it has scavenged. CoQ10 also acts as an anti-oxidant independently, protecting against DNA damage and other forms of oxidative damage.

Coenzyme Q10 is also an essential component of the mitochondria (the "power-house" of the cell), playing a critical role in the formation of ATP, the body's fundamental energy unit, from carbohydrate and fatty acid metabolism.

It appears that Coenzyme Q10 might be involved in maintaining the proper pH of lysosomes, which are a digestive component of cells, as well.2

Coenzyme Q10 and the Heart

In his book, The Doctor's Heart Cure, Dr. Al Sears, MD, director of the south Florida Center for Health and Wellness, devotes an entire chapter to the importance of CoQ10 to the heart.

According to Dr. Sears, coenzyme Q10 prevents arteriosclerosis by reducing the accumulation of oxidized fats in blood vessels, eases high blood pressure, regulates the rhythm of the heart, and improves chest pain and exercise toleration in angina patients.

He describes one woman who came to his Center on statins and two additional blood pressure medications, also suffering from memory loss. A blood test revealed her CoQ10 levels were in the lowest 95% of the population. Supplementing with 200 mg of coenzyme Q10 allowed her to stop both blood pressure medications. She felt "energized," and her memory recovered. Her cardiologist, upon hearing the good news, reacted angrily and threw her bottle of CoQ10 in the trash.3

According to the Linus Pauling Institute's review of coenzyme Q10, controlled intervention studies have shown improvement of congestive heart failure with the administration of coenzyme Q10, although there is conflicting evidence. Animal evidence suggests a significant role for coenzyme Q10 in reducing myocardial damage due to heart attack or open-heart surgery, and collective evidence shows a promising role in reducing high blood pressure.2

Coenzyme Q10 and the Brain

Brain levels of coenzyme Q10 begin declining at the age of 20, and are lowest in the victims of stroke and neurodegenerative diseases.3 Animals with with a Huntington's gene experience fewer brain lesions with CoQ10, but motor improvement and survival benefit is not significant. Evidence is, however, promising for CoQ10 in therapy for Parkinson's.2

Perhaps, if both cholesterol and CoQ10 are important to the function of the brain, coenzyme Q10 deficiency as well as cholesterol depletion might play a role in the side effects sometimes seen from statins associated with memory loss, such as transient global amnesia (TGA).

Coenzyme Q10 in Food

Coenzyme Q10 is found in the highest amounts in red meat products. It is especially high in organ meats such as liver and heart, from which it was first isolated.3 Thus, the combination of cholesterol-lowering statin drugs and a so-called "heart-healthy" regimen free of red meat could dramatically compromise coenzyme Q10 status.

Coenzyme Q10 is also destroyed by heat, so meat should not be overcooked to obtain maximum CoQ10 benefit. Boiling has been found to have negligible effect on the survival of CoQ10, while frying substantially reduces CoQ10, from 14 to 32 percent.4

According to The Doctor's Heart Cure, the organs of wild, grass-fed animals have up to ten times more CoQ10 than the organs of grain-fed animals. "Unless you regularly consume wild game or eat internal organs of grass-fed animals," Dr. Sears writes, "it is difficult to maintain good blood levels of CoQ10 from dietary sources alone."3

If you are interested in finding a source of grass-fed animal products local to you, you can do so by clicking on your state at EatWild.com.

The table below shows the distribution of CoQ10 in 98 different foods. Certain oils, such as soybean, rapeseed, and sesame, have substantial amounts of CoQ10, but samples were taken from Japanese and Finnish retail stores, and it's possible that the oils currently available in the U.S. may be processed in ways that are more injurious to the CoQ10 content. Pending further information, oils shouldn't be considered a reliable source of coenzyme Q10.

Reindeer muscle meat was found to have dramatically higher coenzyme Q10 levels than beef or pork, rivaling those found in the hearts of other animals. The studies from which the data were drawn did not give information on feed, so perhaps this is attributble to the feed of the animal, as Dr. Sears claims.

The table below draws from two different studies. It will be updated soon when I am able to obtain more information.

Supplementing with Coenzyme Q10

Since coenzyme Q10 synthesis declines with age, it becomes more important to obtain it from the diet. For the Standard American Diet (SAD), this essentially means from supplements. Dr. Sears has measured the CoQ10 status of hudreds of patients at the Center for Health and Wellness and reached the following conclusions:

# Young people (those in their twenties and younger) almost always have adequate levels of CoQ10.
# CoQ10 deficiencies are common in people in their forties and beyond.
# Long-duration endurance exercisers tend to have lower levels of CoQ10.
# Deficiencies in CoQ10 are very common in patients with heart disease, high blood pressure, diabetes, or low HDL cholesterol.
# CoQ10 levels are often low in those avoiding red meat and extremely low in vegans.

"If you are in one of these categories, as hundreds of patients discovered, CoQ10 supplements can make a dramatic difference in your energy level and cardiovascular health."

Dr. Sears recommends using gel caps or chewables, and not tablets, and taking the CoQ10 with some fat or oil to increase absorption. More information can be found in his book, The Doctor's Heart Cure

Coenzyme Q10: Hero of the Heart, Victim of the "Heart-Healthy" Establishment

The story of coenzyme Q10 is an ironic one. Coenzyme Q10 is vitally important for the entire body, but has proven especially important to the heart. Yet the "heart-healthy" establishment guidelines hit CoQ10 with a double-whammy: statin drugs hit the body's own synthesis of CoQ10, while red meat and organ meats have both been ridiculed as unhealthy "artery-clogging" foods, yet are the primary source of dietary CoQ10.

Coenzyme Q10 deficiency is not only a "side effect" of statins, it's a side effect of obeying dietary guidelines as well.

As far as using in CCF patient it's still in the pipeline.

Answer 2

1

Answer 3

Yes, one of the side effects of statin drugs is the suppression of the body's formation of Co-enzyme Q10.

Coenzyme Q10 supports energy production in your cells and is especially important to heart health. Studies show that as we age we have less and less of it in our body.

An excellent all natural CoQ10 supplement is CoQHeart.

Hope this is helpful and feel free to contact me with questions.

Answer 4

This is from the American Heart Association

Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like substance in every human cell. It's involved in key biochemical reactions that produce energy in cells. It also acts as an antioxidant (an"tih-OK'sih-dant). CoQ10 is naturally present in a variety of foods. Organ meats such as heart, liver and kidney as well as in beef, soybean oil, sardines, mackerel and peanuts are particularly high in CoQ10.

Less CoQ10 has been observed in some people with cardiac failure due to different causes. Much of the research has been done in patients with congestive heart failure. Some of these studies have shown positive results and others haven't. With one exception, these studies have been done with small numbers of patients for relatively short periods. It's important to note that CoQ10 was given in addition to traditional drug treatments. This makes it hard to know which treatment was the effective one.

The recent ACC/AHA publication "Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult" reviewed the available data. It concluded that until more data are available, nutritional supplements such as coenzyme Q10 cannot be recommended to treat heart failure.

The recent ACC/AHA publication "2002 Guideline Update for the Management of Patients with Chronic Stable Angina" also lists coenzyme Q10 as a treatment that's not useful or effective for patients with angina.

The safety and effectiveness of CoQ10 need to be further evaluated. This requires conducting well-designed clinical trials involving large numbers of patients over a long time. Until that happens, the American Heart Association cannot recommend taking coenzyme Q10 regularly.

Answer 5

Potential side effects of statin drugs: Headache,nausea,vomiting,diarrhea,cons... muscle& joint pain,increase in liver enzymes.The most serious but rare, are liver and muscle failure(rhabdomyolysis) Pregnant women should not take statins.Check with a doctor about drug ,supplement interactions and nutrient depletion

Answer 6

As another said, statins do lower (to some extent) CoQ10. However, randomized, double blinded, placebo controlled trials have failed to show any significant benefit to CoQ10 supplementation.

Answer 7

yes