English Deutsch Français Italiano Español Português 繁體中文 Bahasa Indonesia Tiếng Việt ภาษาไทย
All categories

2 answers

On January 21, 1948, a seminal report by Dr Malcolm M. Hargraves and associates appeared in the Proceedings of the Staff Meetings of the Mayo Clinic.1 This publication, entitled “Presentation of Two Bone Marrow Elements: The ‘Tart’ Cell and the ‘L. E.’ Cell,” marked the first time the phenomenon of nucleophagocytosis in bone marrow preparations was described. The terms LE cell and Tart cell were both coined by Hargraves et al in that report.

The observation of the lupus erythematosus cell led to important gains in understanding the pathogenesis of systemic lupus erythematosus (SLE), but this cell is now considered by most pathologists as being “largely of historical interest.”2 However, the presence of LE cells was considered important enough to be included as a criterion in the most recent (1982) revised criteria for the classification of systemic lupus erythematosus, prepared by the American Rheumatism Association (now the American College of Rheumatology).

There are still rare instances in which the presence of LE cells may be important in the diagnosis of SLE. For example, a case report published in 1992 described 2 brothers with symptoms suggestive of SLE in whom immunologic studies, including antinuclear antibody assays, were unrevealing. An LE cell preparation showed positive results in both patients and helped support the diagnosis of SLE. The history of the LE cell and its role in furthering the understanding of SLE were recently reviewed.

While the LE cell has diminished in importance since its original description in 1948, the Tart cell has fallen into complete obscurity. Seven major textbooks on clinical hematology and 7 on immunology published since 1980 were reviewed, but none mentioned the Tart cell. Relatively few pathologists and immunologists are aware of the existence of the Tart cell, especially those trained within the past decade.

2007-06-14 06:55:44 · answer #1 · answered by Dr.Qutub 7 · 0 0

this comes right off of the Lupus Foundation of americas sight about the criteria:

To assist the physician in the diagnosis of lupus, the American College of Rheumatology (ACR) in 1982 issued a list of 11 symptoms or signs that help distinguish lupus from other diseases.

Is that what you were talking about? Hope that helps...you can check out there site at lupus.org

2007-06-14 11:21:22 · answer #2 · answered by Mleigh23 2 · 0 0

fedest.com, questions and answers