The fact that type 1 diabetes is due to the failure of one of the cell types of a single organ with a relatively simple function (i.e. the failure of the islets of Langerhans) has led to the study of several possible schemes to cure this form diabetes mostly by replacing the pancreas or just the beta cells. In contrast, type 2 diabetes is more complex, with fewer prospects of a curative measure, but further understanding of the underlying mechanism of insulin resistance may make a cure possible in the future. Correcting insulin resistance would provide a cure for type 2 diabetes in many cases.
Only those type 1 diabetics who have received a kidney-pancreas transplant (when they have developed diabetic nephropathy) and become insulin-independent may now be considered "cured" from their diabetes. Still, they generally remain on long-term immunosuppressive drug and there is a possibility the autoimmune phenomenon will develop in the transplanted organ.
Transplants of exogenous beta cells have been performed experimentally in both mice and humans, but this measure is not yet practical in regular clinical practice. Thus far, like any such transplant, it has provoked an immune reaction and long-term immunosuppressive drugs will be needed to protect the transplanted tissue. An alternative technique has been proposed to place transplanted beta cells in a semi-permeable container, isolating and protecting them from the immune system. Stem cell research has also been suggested as a potential avenue for a cure since it may permit regrowth of Islet cells which are genetically part of the treated individual, thus perhaps eliminating the need for immuno-suppressants. However, it has also been hypothesised that the same mechanism which led to islet destruction originally may simply destroy even stem-cell regenerated islets. A 2007 trial of 15 newly diagnosed patients with type 1 diabetes treated with stem cells raised from their own bone marrow after immune suppression showed that the majority did not require any insulin treatment for prolonged periods of time.
Microscopic or nanotechnological approaches are under investigation as well, in one proposed case with implanted stores of insulin metered out by a rapid response valve sensitive to blood glucose levels. At least two approaches have been demonstrated in vitro. These are, in some sense, closed-loop insulin pumps.[citation needed]
A new discovery might have important implications for treatment of diabetes. Researchers at the Toronto Hospital for Sick Children injected capsaicin into NOD mice (Non-obese diabetic mice, a strain that is genetically predisposed to develop the equivalent of type 1 diabetes) to kill the pancreatic sensory nerves. This treatment reduced the development of diabetes in these mice by 80%, suggesting a link between neuropeptides and the development of diabetes. When the researchers injected the pancreas of the diabetic mice with sensory neuropeptide (sP), they were 'cured' of the diabetes for as long as 4 months. Also, insulin resistance (characteristic of type 2 diabetes) was reduced. These research results are in the process of being reproduced, and their applicability in humans will have to be established in future. Any treatment that might result from this research is probably years away.
2007-04-13 17:49:34
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answer #1
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answered by shiva 3
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2016-05-18 19:07:32
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answer #2
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answered by ? 3
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I am surprised you are still alive! You
could have seriously impaired your
eyesight and your kidney function. Did
you not feel faint? You could have gone into coma and not come out! Are you monitoring your glucose levels?
Taking your insulin means nothing.
You need a specific program to decide
exactly how much insulin you need per
day. You need to know how to use
short term and long term insulin.
Do you have any doctor's oversight
at all? Insulin will cause weight gain.
The insulin you inject is the same as
if you had no diabetes because the
alternate insulin is filling your cells
with the proper amount of glucose
for health and life.
You had best educate yourself on
proper diet as a diabetic. You can eat
just about anything, just keep the carbs way down. Get some books on
diet. You don't have to be hungry all
the time.You just can't fill up with
pastas and sweets. If you want to
live to a ripe old age--it is imperative
that you control this disease.
2007-04-13 18:09:31
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answer #3
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answered by Anonymous
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2016-09-17 15:22:30
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answer #4
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answered by ? 3
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I did the same as you a fews ago,and to get myself back on track,I had to go back to the hospital and get some more education from my diabetes nurse.Mind you if you had lost 25 pounds,and you have gained 5 pounds,you still have a net loss of 20 pounds,so I don't think thats a problem.It seems as though your insulin levels are too high,it can't be rejection,as you must be using one of the human insulins that are availableeg Actrapid,or Humalog.A good idea when you are eating is to eat what you want,but try to stay off the soft drinks,and the sweets.You probably know all that anyway.It sounds like your body is balancing itself out ,after all the years of neglect.I'm sure it will come good,but in the mean time go to your doctors,and get the needed blood tests,check out BSLs.HBALC.u&e's GOOD LUCK
2007-04-13 17:59:15
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answer #5
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answered by Anonymous
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I'm a 45 year old woman and was recently diagnosed as being a borderline diabetic. My doctor prescribed some medication, but before filling it I decided to do some research on the internet which led me to the methods. After reading this ebook and applying the methods, my scepticism turned to 100% belief. I noticed that my energy levels increased significantly and I felt more rested in the morning, my symptoms started going away.
I am very happy to tell you that I have been feeling better than I have felt in years and my doctor informed me that he will be taking me off my prescriptions if I keep this up.
I recommend you use the Type 2 Diabetes Destroyer to naturally reverse your diabetes.
2016-05-17 00:06:02
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answer #6
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answered by ? 4
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assuming you have type two diabetes....
insulin can make you gain weight, so that's why you lost and why you're gaining now. don't stop your insulin w/o your doc telling you to, it's extremely dangerous for your body. you can better control your blood sugar with exercise and diet. a diet that's low in sugars (think low carb/south beach). high in veggies and protein, low in carbs and sugar (including sugars in fruits). proteins may not fill you up as much, but they actually control your appetite longer than carbs do (which can give you a sudden burst and fill you up, but are burned up quickly and also raise your blood sugar).
when you stopped the insulin you lost weight because all the glucose from the food you ate was not absorbed, instead it just waited to get filtered out by the kidneys (very bad for the kidneys). you lost weight because you essentially were not absorbing the glucose that results from the breakdown of the foods you eat.
again, diabetic control is VERY important, especially if you're diabetic at such a young age. after time, uncontrolled diabetes can lead to loss of vision, kidney damage/failure, and decreased sensation/blood flow to your extremities. most the people you see now that have had amputations are the result of poor diabetic control and a wound that gets infected and infects the bone (which MAY be cleared up by 6 weeks of IV antibiotics).
2007-04-13 17:50:23
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answer #7
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answered by bt 4
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The American Diabetes Association has several tips on eating and getting back on track.
First thing is get your blood sugars checked if you haven't already. Check you A1C and make certain you know where your starting point is and that its accurate.
Second - get rid of anything white; sugar, rice, flour, corn, bread, fries, potatoes, etc. You need to get into eating more protein and also complex carbs - whole grains, beans, veggies, salads, etc. to feel like you've eaten enough at meal time.
Also plan on a light snack between meals; nuts, dried fruits, yogurt - natural with no sugar - and other whole grain snacks.
Stay with the plan and you'll gain a little more weight. One medication to check on with your doctor is Byetta - it helps bring the insulin into the bloodstream easier and assists with limiting weight gain as well. Good luck
2007-04-13 18:47:46
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answer #8
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answered by Anonymous
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Forget anything you have ever been told about Diabetes.
And get this - it has nothing to do with insulin, exercise, diet or anything else you've heard in the past. It's all based on latest breakthrough research that Big Pharma is going Stir Crazy to hide from you.
Visit here : https://tr.im/KfVg2 to find out what all the fuss is about.
2016-02-16 18:42:59
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answer #9
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answered by Anonymous
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First, congratulations for recognizing that not taking your insulin and eating anything was not good for you.
One of the big symptoms of diabetes is weight loss, which you have had.
I think a good next step would be to [re]connect with an endocrinologist, get your A1C taken, and check with a nutritionist. Most endocrinologist have nutritionists on staff. Get some good recommendations from him/her. Alternate sources for good foods include:
http://www.diabetes.org/nutrition-and-recipes/nutrition/healthyfoodchoices.jsp
http://www.diabetes.org/nutrition-and-recipes/nutrition/webbcooks.jsp
http://www.diabetic-recipes.com/
Also, most manufacturers of glucose meters and other diabetic supplies have web pages with suggested recipes.
Good luck, and stick to it.
2007-04-14 08:24:49
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answer #10
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answered by istitch2 6
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