Secondary breast cancer?

Question

We found out that my mom's chemo therapy was not working for her cancer, which came back in other areas of her body (not major organs) and now the doctors are suggesting clinical trials or hormone therapy. Has anyone heard of any results of the hormone therapy for recurring breast cancer? Does it work?

Answer 1

N0V-002 (novo-two) is a New adjunct medication used with standard chemotherapy

currently being tested for approval in the USA.

Increased the ability of patients to tolerate Chemo to the full 100%
Increased the Cancer Survival rate by 80%

Clinical Trials available now.
They are accepting some patients under FDA Fast Track SPA Phase III in the USA.

See "Got the Script" message on this board, Novo Two is available outside US:

http://messages.finance.yahoo.com/mb/NVLT.OB

Novelos' pipeline of drugs is based on oxidized glutathione, a natural metabolite that is part of the glutathione pathway. This pathway is the primary determinant of intracellular redox (oxidation/reduction) potential and, as such, plays a key role in cell protection (e.g. detoxification) and in regulation of cell signaling pathways (e.g. leading to cytokine production). Novelos’ lead products are believed to act, in part, via post-translational modification (glutathionylation) of critical regulatory proteins that mediate processes including immune function, cell proliferation and tumor progression (in combination with chemotherapy). They may also sensitize tumor cells to certain chemotherapeutic drugs by modifying drug detoxification processes.

Answer 2

If her original breast cancer was hormone receptor positive there is a good chance hormone treatments can help her for a long time, especially if it's in the bones (is that where it is?).

If she hasn't had a biopsy since the cancer recurred, and it's possible to get one, you might want to request that. Cancers can change their hormonal status.

Herceptin that someone mentioned is NOT for hormone receptor positive cancers specifically. It is for cancers that overexpress a certain receptor called HER-2. If your mom's tumor had that she would be eligible for that.

Do you have her pathology reports? There is information on there about hormone receptor status and hopefully HER-2 status.

Tamoxifen is the age old standard for hormone therapy, but there is a new class of drugs called aromatase inhibitors. I am assuming she is postmenopausal, so she would be eligible for those.

The advantage of doing hormone therapy now is it is less toxic. So if she needs further treatment down the road, such as chemo, her body will be able to handle it. If you do more chemo now, it may be too much for her to take.

Answer 3

There have been good results for hormone therapy in estrogen receptive breast cancers. Herceptin and Tamoxifen are two drugs that I'm aware of.

Check Dr. Susan Love's website she is an authority on the human breast and the latest research, and treatments...

Answer 4

Secondary isn't good and in lots of cases there isnt lots which would be carried out.My spouse had breast maximum cancers and then on a later x ray the professional advised her that she had lung maximum cancers.I rang maximum cancers back up and that they advised me that if it replace into secondary then it replace into no longer a hopeful consequence.thankfully the professional replace into very incorrect and a extra test confirmed that it replace into scar tissue on the lung from radiotherapy.She lived.It relies upon how sturdy your pal is.seem how long Jane Tomlinson went on for

Answer 5

Be sure to get a genetic test to see if her body is capable of converting Tamoxifen to the active form. This test was not done for my mom and the cancer returned and spread. If she were tested she could have received aromatase inhibitors and might still be alive.

Answer 6

iv heard of the hormone therapy however some are effective and others arnt my aunt had to have hormone therapy and so far so good stay strong and be possitive.