While mutations have been observed in many different genes, they have not been isolated in histones. Why does this seem reasonable? If you wanted to make antibodies to histones, would it be easy?
2007-03-25 05:35:52 · 3 answers · asked by Tiff 1 in Science & Mathematics ➔ Medicine
Histones are large, globular proteins present in the nucleus. They are what DNA wraps around to form chromatin. Histones do not carry genetic information. It is possible to make antibodies to histones and it occurs in some disease states, specifically, auto-immune diseases, specifically, Mixed conective tissue diseases and possibly Sjogren's syndrome. It would be easy to make antibodies artificially. Just extract and purify the histone proteins and innoculate some animal along with freund's adjuvant. If there is enough difference between human and animal histones then there should be little problem as long as the protein doesn't denature.
2007-03-25 07:09:48 · answer #1 · answered by misoma5 7 · 1⤊ 0⤋
It might be easier to find a chemical that split the protein so it can't function. Perhaps a sulfa drug? Maybe you can find a bacterial or viral carrier.
2007-03-25 06:15:37 · answer #2 · answered by nursesr4evr 7 · 0⤊ 0⤋
huh? u lost me...i mean sure i dont see why not. thats a great idea!!
2007-03-25 05:46:04 · answer #3 · answered by Muhh-liss-Uhh 2 · 0⤊ 0⤋