explain how a cell,s production of thyroxin would be effected if its lysosomes were not functioning?

Answer 1

protein degradation
Protein degradation is energy-dependent and occurs under two conditions:

physiologically:
as a means of destroying proteins which have formed abnormally
as a means of reducing enzyme concentrations and so altering flux through metabolic pathways
within cells which are subject to digestive enzymes
pathologically e.g. during prolonged starvation
Within cells, protein degradation can occur:

within lysosomes:
particularly in liver
contain abundant proteinases
within reticulocytes: contain cyosolic proteases
within muscle:
peptidases activated by calcium
degrade myofibrillar proteins
Amino acids so produced are then available for the normal pathways of amino acid metabolism.

Little is understood about the general control of protein degradation, but the regulation of skeletal muscle is better characterized:

anabolic hormones such as insulin decrease protein degradation
glucocorticoids and thyroxine have the reverse effect
amino acid degradation
insulin
glucagon
glucocorticoids
thyroxine
lysosomes
reticulocytes