I understand that TTP a measure of time...but what about PFS? Is it a measure of time or is it a rate? What group of subjects is censored for each of these two measurements (e.g., non-progressive, alive)?
2007-03-09 10:15:29 · 2 answers · asked by AC 2 in Health ➔ Diseases & Conditions ➔ Cancer
PFS can also be described by time, while others may also describe it as a form of rate. For example, a cohort of patients may have a median PFS of 6 months, or you can say that for the entire cohort, the 6 month PFS is 50%.
Generally, for TTP the censored time is when a disease actually progresses, while for PFS, it is at the time of disease progression or death, whichever comes first. But in many cases, I consider the two terms interchangeable.
2007-03-09 12:35:52 · answer #1 · answered by Cycman 3 · 0⤊ 0⤋
PFS measures survival time that is free of disease progression. TTP measures the Time To Progression without taking survival time into account.
Another way of saying is that PFS is measuring survival time, and TTP is measuring progression time.
2007-03-10 00:24:44 · answer #2 · answered by Bob 5 · 0⤊ 0⤋