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2007-03-09 04:22:24 · 1 answers · asked by Desiree M 1 in Science & Mathematics Medicine

1 answers

Phencyclidine (a contraction of the chemical name phenylcyclohexylpiperidine), abbreviated PCP, is a dissociative drug formerly used as an anesthetic agent, exhibiting hallucinogenic and neurotoxic effects. It is commonly known as Angel Dust .

PCP was commercially developed in the 1950s by the Parke-Davis pharmaceutical company. PCP is listed as a Schedule II drug in the United States under the Convention on Psychotropic Substances.[1]
Contents
Chemistry and pharmacology

Chemically PCP is an arylcyclohexylamine derivative, and pharmacologically, it is a member of the family of dissociative anesthetics. PCP works primarily as an NMDA Receptor Antagonist which blocks the activity of the NMDA Receptor. Other NMDA Receptor Antagonists include ketamine, tiletamine, and dextromethorphan. Although the primary psychoactive effects of the drug only last hours, total elimination from the body is prolonged, typically extending over weeks.

More than 30 different analogues of PCP were reported as being sold on the street during the 1970s and 1980s, mainly in the USA. The best known of these were PCPy (Rolicyclidine, 1-(1-phenylcyclohexyl)pyrrolidine); PCE (Eticyclidine, N-ethyl-1-phenylcyclohexylamine); and TCP (Tenocyclidine, 1-(1-(2-Thienyl)cyclohexyl)piperidine). These compounds were never widely used and did not seem to be as well accepted by users as PCP itself, however they were all added onto Schedule I of the Controlled Substance Act because of their presumably similar effects. [2]

The generalised structural motif required for PCP-like activity is derived from structure-activity relationship studies of PCP analogues and summarised below. All of these analogues would presumably have somewhat similar effects to PCP itself, although with a range of potencies and varying mixtures of anaesthetic, dissociative and stimulant effects depending on the particular substituents used. In some countries such as the USA, Australia and New Zealand, all of these compounds would be considered controlled substance analogues of PCP and are hence illegal drugs, even though many of them have never been made or tested.
Effects

The neutrality of this article is disputed.
Please see the discussion on the talk page.

PCP has potent effects on the nervous system altering perceptual functions (hallucinations, delusional ideas, delirium or confused thinking), motor functions (unsteady gait, loss of coordination, and disrupted eye movements or nystagmus), and autonomic nervous system regulation (rapid heart rate, altered temperature regulation). The drug alters mood states in an unpredictable fashion causing some individuals to become detached and others to become animated. Intoxicated individuals may act in an unpredictable fashion driven by their delusions or hallucinations. Included in the portfolio of behavioral disturbances are acts of self injury including suicide, and attacks on others or destruction of property. Unfortunately the anesthetic properties of the drug cause violent individuals to feel less pain at the time and persist in violent or injurious acts as a result. Recreational doses of the drug induce a psychotic state that resembles schizophrenic episodes.

Police and firefighters often consider individuals under the influence of PCP to be highly dangerous and unpredictable; members of the Los Angeles Police Department justified their use of violent force against Rodney King by claiming he appeared to be under the influence of the drug.

In popular culture, a widespread mythology has developed around PCP use, often attributing superhuman strength and self-mutilation to the effects of PCP consumption; for example the abnormal strength and actions of robots in the Terminator movies and vampires in Buffy the Vampire Slayer are written off by authorities as those of PCP junkies.

2007-03-10 07:28:31 · answer #1 · answered by Dr.Qutub 7 · 0 0

PCP (phencyclidine) is most often called "angel dust." It was first developed as an anesthetic in the 1950s. However, it was taken off the market for human use because it sometimes caused hallucinations.

PCP is available in a number of forms. It can be a pure, white crystal-like powder, or a tablet or capsule. It can be swallowed, smoked, sniffed, or injected. PCP is sometimes sprinkled on marijuana or parsley and smoked.

Although PCP is illegal, it is easily manufactured. It is often sold as mescaline, THC, or other drugs. Sometimes it may not even be PCP, but a lethal by-product of the drug. Users can never be sure what they are buying since it is manufactured illegally.

2007-03-12 02:32:58 · answer #2 · answered by ivette o 2 · 0 0

Phencyclidine (a contraction of the chemical name phenylcyclohexylpiperidine), abbreviated PCP, is a dissociative drug formerly used as an anesthetic agent, exhibiting hallucinogenic and neurotoxic effects. It is commonly known as Angel Dust .

PCP was commercially developed in the 1950s by the Parke-Davis pharmaceutical company. PCP is listed as a Schedule II drug in the United States under the Convention on Psychotropic Substances

Chemically and pharmacologically it is a member of the family of dissociative anesthetics. PCP works primarily as an NMDA Receptor Antagonist which blocks the activity of the NMDA Receptor. Other NMDA Receptor Antagonists include ketamine, tiletamine, and dextromethorphan. Although the primary psychoactive effects of the drug only last hours, total elimination from the body is prolonged, typically extending over weeks.

PCP was first tested after World War I as a surgical anesthetic. Because of its adverse side-effects, it was shelved until the 1950s. It was then patented by Parke-Davis and named Sernyl (supposedly referring to serenity), but was again withdrawn from the market because of side effects. It was soon renamed Sernylan, and marketed as a veterinary anaesthetic, but again discontinued. Its side effects and long half-life in the human body made it unsuitable for medical applications. It is retained in fatty tissue and is broken down by the human metabolism into PCHP, PPC and PCAA. When smoked, some of it is broken down by heat into 1-phenyl-1-cyclohexene (PC) and piperidine.

Effects
Whether PCP has any strong and consistent effects which are markedly different from other similar compounds is controversial. Some think that the drug's effects are as varied as its appearance. It may be that a moderate amount of PCP will cause users to feel detached, distant, and estranged from their surroundings. Numbness, slurred speech, and loss of coordination may be accompanied by a sense of strength and invulnerability. A blank stare, rapid and involuntary eye movements, diarrhea, and an exaggerated gait are alleged to be among the more observable effects. PCP can sometimes elevate body temperature, which is why many people under the influence of PCP have been known to shed clothing in public places. However, there is no scientific evidence that PCP induces violence. It is alleged that PCP could cause extreme vivid hallucinations of things that are out of the ordinary and bizarre, claimed by those who use it.

According to the National Institute on Drug Abuse: at high doses of PCP, blood pressure, pulse rate, and respiration drop. This may be accompanied by nausea, vomiting, blurred vision, nystagmus, drooling, loss of balance, and dizziness. High doses of PCP can also cause seizures, coma, and death (though death more often results from accidental injury or suicide during PCP intoxication). High doses can cause symptoms that mimic schizophrenia, such as delusions, hallucinations, paranoia, disordered thinking, a sensation of distance from one’s environment, and catatonia. Speech is often sparse and garbled.

2007-03-12 05:39:17 · answer #3 · answered by Philomena 5 · 0 0

a very powerful halucinogen that can cause many different reactions. There is no way to determine how any amount will effect you, and the drug effect everyoen differently. The worst case scenarios include self mutilation, murder, suicide, rape, various other crimes, and death just by taking it. PCP is not a drug that should be used. Not only can it cause you to hallucinate temporarily, but it could cause you to have flashbacks for the rest of your life, or take your sanity completely

2007-03-09 05:28:13 · answer #4 · answered by Anonymous · 0 0

Phencyclidine. It's an analgesic (painkiller) for horses. It has no real use for humans...other than to have wild hallucinations. I cannot imagine why anyone would want to take PCP unless they had a death wish and/or were extremely masochistic.

2007-03-09 04:44:11 · answer #5 · answered by Anonymous · 0 0

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