Why can't Doctors inject you with HDL?

Question

It seems that science should be able to manufacture HDL and then be able to add it to the bloodstream via some method. Sounds simple but I'm sure it's not. Probably has to do with blood chemistry and metabolism. Thanks

Answer 1

Raising HDL

Given this data, one could ask why more attention is not paid to raising HDL levels rather than lowering LDL levels. The answer to this question is multifaceted. In part, the reason is that LDL cholesterol drew early researchers' attention more than did HDL. Hence, much of the thrust of cholesterol research (including clinical trials) was directed at the effects of lowering LDL. Likewise, pharmaceutical company research enjoyed early success at developing medicines to lower LDL. Taken together, these factors tended to thrust LDL into the "limelight". On the other hand, although epidemiologically more important than LDL, efforts to emphasize the benefit of raised HDL came later. In large part this was due to the absence of effective, safe, and well-tolerated medicines with which to increase HDL. Although the use of niacin and fibrates will often lead to increased HDL levels, the former is poorly tolerated, and both have a number of other effects on cholesterol and triglyceride levels (meaning that no conclusions could be drawn on the basis of their ability to raise HDL, but, instead, would have to be based on their total spectrum of effects on blood lipids). Finally, at this point (2007), both physicians and the lay public have been instructed and educated for years with respect to the "whys" and the "how-to's" of LDL lowering. To change the paradigm at this stage would take a huge (and expensive) effort.

As of 2006, randomized clinical trials have demonstrated significant reduction of atherosclerosis progression and cardiovascular events with treatments that increase HDL-cholesterol (nicotinic acid or a fibrate). [5]

Pharmacological therapy to increase the level of HDL cholesterol includes use of fibrates and niacin. Consumption of niacin, an immediate release crystallin form of Vitamin B3, can increase HDL levels by 15–30%, and is the most powerful agent currently available to increase HDL-cholesterol. [6] [7] The use of statins is effective against high levels of LDL cholesterol, but it has little or no effect in raising HDL-cholesterol.[8] The use of antioxidants in combination with statin and niacin therapy reduces the effectiveness of Niacin by 33%. (NIH HATS).

Torceptrapid, a promising new drug developed by Pfizer to raise HDL by inhibition of cholesteryl ester transfer protein (CETP), was terminated after several patients suddenly died during the trial study.

Certain changes in lifestyle can have a positive impact on raising HDL levels:[9]

Answer 2

and why not to increase HDL in your diet, you can mostly find it in olive oil, isn't that easier