CLINICAL PHARMACOLOGY
Therapeutic doses of ephedrine produce mainly relaxation of smooth muscle and, if norepinephrine stores are intact, cardiac stimulation and increased systolic and usually increased diastolic blood pressure. Its vasopressor effect results largely from increased cardiac output and to a lesser extent from peripheral vasoconstriction. Pressor responses to parenteral ephedrine are slower but more prolonged than those produced by epinephrine. Ephedrine stimulates both alpha and beta receptors and its peripheral actions are due partly to norepinephrine release and partly to direct effect on receptors. Ephedrine may deplete norepinephrine stores in sympathetic nerve endings, so that tachyphylaxis to cardiac and pressor effects of the drug may develop. Central nervous system effects are similar to those of amphetamine drugs but less pronounced. The central effects of ephedrine are overshadowed to a large extent by its peripheral actions. Glycogenolysis in the liver is increased by ephedrine but not as much as by epinephrine; usual doses of ephedrine are unlikely to produce hyperglycemia. Ephedrine increases oxygen consumption and metabolic rate as a probable result of central stimulation.
Ephedrine is rapidly and completely absorbed following parenteral injection. Pressor and cardiac responses to ephedrine persist for one hour following intramuscular or subcutaneous administration of 25 to 50 mg.
IT IS NOW A CONTROLLED BY FDA, AND WAS USED PREVIOUSLY FOR TREATMENT OF BR.ASTHMA/STATUS ASTAMATICUS IN 5 Mg DOSE, BUT BE A POTENT CNS STIMULANT GIVEN IN HIGHER DOSE RESULTS IN INSOMNIA. DISCONTINUED THROUGHOUT THE WORLD BECAUSE OF "COREX", A MEDICINE FROM PFIZER USED FOR COUGH, AND ABUSE.
2007-02-12 07:52:03
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answer #1
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answered by Dr.Qutub 7
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It is the main ingredient needed to manufacture methamphetanine. Several over the counter meds used to contain ephedrine but the DEA has limited the amount an individual can purchase legally.
2007-02-12 15:25:06
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answer #2
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answered by Anonymous
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Ephedrine is commonly used as a stimulant, appetite suppressant, concentration aid, decongestant and to treat hypotension, it is banned in the UK. It can be used by athletes and body builders to gain performance.
2007-02-12 15:22:44
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answer #3
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answered by huggz 7
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