aminophylline infusion must it go thru a pump?

Answer 1

Interesting question, why under diabetes. Aminophylline is an old drug which as a young GP I always carried in my bag as the mainstay for acute asthma attacks.It replaced adrenaline.Soon after I entered practise is was replaced by nebuliser therapy. We were always taught to give it as a bolus injection over no less than ten minutes and then to set up an infusion if needed. As time went on concerns grew and the instruction was added that it should only be given with the patient on an ECG machine in case heart rhythm problems developed. It is still used in hospital only, the current SIGN guideline on asthma says it should only be given by senior staff in patients with severe asthma that has not responded to nebuliser therapy. In these cases a loading injection is used unless the patient is taking a theophylline by mouth.

Answer 2

Aminophylline should only be given by SLOW intravenous injection or infusion at about 1 ml per minute. Plasma theophylline levels should be maintained between 10 and 20 mg/l. Levels should be monitored pre and post dosing.
Loading dose:
5mg/kg over 20-30 minutes. If patient already has plasma level of theophylline, (e.g. from previous tablets or capsules), reduce loading dose accordingly. Assume each mg/kg aminophylline will increase plasma concentration by 2mg/l.
Maintenance dose (by slow iv infusion):
Age group Dose
6 months - 9 years 1mg/kg/hr.
10-16 years 0.8mg/kg/hr.
Adults 0.5mg/kg/hr
Elderly or patients with cor pulmonale 0.3mg/kg/hr
Congestive heart failure or liver failure 0.1-0.2mg/kg/hr

Answer 3

Many common natural remedies are claimed to have blood sugar lowering properties that make them useful for people with or at high risk of diabetes. Learn here https://tr.im/Xfb0k

A number of clinical studies have been carried out in recent years that show potential links between herbal therapies and improved blood glucose control, which has led to an increase in people with diabetes using these more 'natural' ingredients to help manage their condition.

Answer 4

1