How do calcium channel blockers help to reduce blood pressure?

Answer 1

Calcium channel blockers work by blocking L-type voltage gated calcium channels (VGCC) in the heart and in the blood vessels. This prevents calcium levels from increasing as much in the cells when stimulated, leading to less contraction.

This decreases total peripheral resistance by dilating the blood vessels, and decreases cardiac output by lowering the force of contraction. Because resistance and output drop, so does blood pressure.

With low blood pressure, the heart does not have to work as hard; this can ease problems with cardiomyopathy and coronary disease.

Unlike with beta-blockers, the heart is still responsive to sympathetic nervous system stimulation, so blood pressure can be maintained more effectively.

Answer 2

They stop calcium build up..In the heart and Blood vessels..