Are THERE ORGANISMS WITH CYSTIC FIBROSIS?

Question

Are THERE ORGANISMS WITH CYSTIC FIBROSIS?
besides humans? what and can u send me a link or something about it please??
thanks
=]

Answer 1

The simple answer to your question is NO

Cystic fibrosis is the most common life-limiting autosomal recessive disease among people of European heritage. In the United States, approximately 30,000 individuals have CF; most are diagnosed by six months of age. Canada has approximately 3,000 citizens with CF. Approximately 1 in every 25 people of European descent and 1 in every 29 people of Ashkenazi Jewish descent is a carrier of a cystic fibrosis mutation. Although CF is less common in these groups, approximately 1 in every 46 Hispanics, 1 in every 65 Africans and 1 in every 90 Asians carry at least one abnormal CFTR gene.

Cystic fibrosis is diagnosed in males and females equally. For unclear reasons, males tend to have a longer life expectancy than females. Life expectancy for people with CF depends largely upon access to health care. In 1959, the median age of survival of children with cystic fibrosis was 6 months. In the United States, the life expectancy for infants born in 2006 with CF is 36.8 years, based upon data compiled by the Cystic Fibrosis Foundation. Similarly, in much of the western world people with CF live to a similar age. However, the life expectancy in underdeveloped countries is much less — the majority of individuals with CF do not live past the age of ten.

The Cystic Fibrosis Foundation also compiles lifestyle information about American adults with CF. In 2004, the foundation reported that 91% had graduated high school and 54% had at least some college education. Employment data revealed 12.6% of adults were disabled and 9.9% were unemployed. Marital information showed that 59% of adults were single and 36% were married or living with a partner. In 2004, 191 American women with CF were pregnant.


Theories about the prevalence of CF
The ΔF508 mutation is estimated to be up to 52,000 years old. Numerous hypotheses have been advanced as to why such a lethal mutation has persisted and spread in the human population. Other common autosomal recessive diseases such as sickle cell anemia have been found to protect carriers from other diseases, a concept known as heterozygote advantage. With the discovery that cholera toxin requires normal host CFTR proteins to function properly, it was hypothesized that carriers of mutant CFTR genes benefited from resistance to cholera and other causes of diarrhea. Further studies have not confirmed this hypothesis.

Normal CFTR proteins are also essential for the entry of Salmonella typhi into cells, suggesting that carriers of mutant CFTR genes might be resistant to typhoid fever. No in vivo study has yet confirmed this. In both cases, the low level of cystic fibrosis outside of Europe, in places where both cholera and typhoid fever are endemic, is not immediately explicable.

Answer 2

If you don't count lab rats that were grown to exhibit certain aspects of CF, no, there are no other organisms besides humans with CF. From PubMed:

"Cystic fibrosis, a genetically inherited disease of the exocrine glands in man, has no known counterpart in animals. The symptoms in man produced by mucous obstructing the lungs, pancreas and liver have been described. The signs, symptoms and course of an analogous disease in animals have been predicted. If an analogous disease in animals can be discovered, it is anticipated that it will make possible significant advances in the study of the normal and pathological physiology of the abnormal exocrine glands and will lead to a means of controlling the human disease."

Answer 3

i don't have an answer on your question, besides the shown fact that, I purely had to need you the superb of success. I purely those days started gaining knowledge of approximately Cystic Fibrosis as i'm playing interior the international's Longest Hockey pastime 4 CF, and elevating money to attempt to discover a therapy. you're all magnificent youthful beings for scuffling with so complicated. with a bit of luck a therapy would be got here across quickly.

Answer 4

Only humans if that is the question.