What is an over the counter drug that works on the Endorcine system?

Answer 1

CODEINE (common in OTC cold and flu medications) has an indirect effect on the endocrine system, by suppressing the production of several hormones produced by the body. The following is a copy of the 'mechanism of action" description of codeine, from the University of Alberta Drugbank Database.

"Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. OPIOIDS ALSO INHIBIT THE RELEASE OF VASOPRESSIN, SOMATOSTATIN, INSULIN AND GLUCAGON. Codeine's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability."

Answer 2

Beer does a great job of suppressing the secretion of antidiuretic hormone. You'll pee for hours.
Actually, you need to be more specific in your question, or else you're about to be taken by some snake-oil salesman selling you something with vague promises of "regulating your endocrine system." I hope it isn't the latter..

Answer 3

Your question is too vague. The endocrine system (hormones, etc.) is very complex and you would need to describe a specific problem within the system to get a good answer.