I need web site references for complications of Vitamin B12 .?

Question

As a young student a prof. told us that some individuals with an underlying neuro problem could start fitting if B12 was given in larger doses.
The Prof is dead and I was young at the time. The prof was correct in almost every bit of advice she gave even before some of the research was done!

Answer 1

Hi Mima,
I am not sure which neuro problem the prof was referring to...
so when I searched Pub Med (see below for Pub Med explanation), I searched for neurological problems very broadly,
and might have missed some.

Anyways...here is one artifcIe of 25 that seemed to be the closest fit...

Syncope following intramuscular injection of hydroxocobalamin in a paraplegic patient: indication for oral administration of cyanocobalamin in spinal cord injury patients.

Vaidyanathan S, Soni BM, Oo T, Watt JW, Sett P, Singh G.
Regional Spinal Injuries Centre, District General Hospital, Southport, Merseyside, UK.

Spinal Cord. 1999 Feb;37(2):147-9. [No abstract available]

As I said, I searched rather generally, so I might have missed a few neurological diseases...if you have a specific neuro problem
or group of neuro problems, that would help me narrow it down.
If you think I could be of further help, just email me!
Be glad to work on it more.

Answer 2

As far as neurological signs associated with administration of cyanocobalamin (B12), I know of none. However, B12 deficiency can cause demyelination and irreversible nerve cell death. Symptoms include numbness or tingling of the extremities and an ataxic gait, a syndrome known as "subacute combined degeneration of the cord". Additionally, administration of high concentrations of dextrose to a patient suffering from B12 deficiency can cause ataxic symptoms - Wernicke's encephalopathy. You can go to the website below for a little more info if you like.

Answer 3

try www.medicinenet.com and www.drugsdigest.com