in relation to botulism
2006-12-18 15:58:19 · 6 answers · asked by oohmilala 1 in Health ➔ Diseases & Conditions ➔ Respiratory Diseases
Acetylcholine is a neurotransmitter which stimulates nerves.
Botulism toxin cleaves parts of the neuromuscular synapse preventing release of acetylcholine. because Acetyl choline remains bound to its receptor- the nerve becomes over stimulated (also prevents feedback inhibition) which eventually leads to decrease control over respiratory muscles leading to respiratory paralysis and death. This is a simplification of complex interactions between acetylcholine, botulism toxin and the acetylcholine receptors throughout the body
2006-12-18 16:12:59 · answer #1 · answered by pedidoc43 3 · 0⤊ 0⤋
Acetylcholine is liberated at nerve endings as a neurotransmitter. It is particularly important in the stimulation of muscle tissue. The transmission of an impulse to the end of the nerve causes it to release neurotransmitter molecules onto the surface of the next cell, stimulating it. After such release, the acetylcholine is quickly broken into acetate and choline, which pass back to the first cell to be recycled into acetylcholine again. The poison curare acts by blocking the transmission of acetylcholine. Some nerve gases operate by preventing the breakdown of acetylcholine causing continual stimulation of the receptor cells, which leads to intense spasms of the muscles, including the heart. Acetylcholine is often abbreviated as Ach.
In botulism,which is caused by Clostridium Botulinum,a bacteria found in soil,the toxin released by the bacteria binds to nerve endings,preventing the release of acetylcholine.This leads to paralysis and in severe cases,a need for mechanical ventilation[as the patient is unable to breathe due to paralysis of the respiratory muscles and diaphragm].
Three forms of naturally occurring botulism affecting humans exist: foodborne, wound, and intestinal. All forms of botulism result from absorption of botulinum toxin into the bloodstream. The toxin does not penetrate intact skin. Inhalational botulism is a man-made form of disease that results from inhaling aerosolized botulinum toxin.
Hope that is good enough to help you.
2006-12-18 16:26:17 · answer #2 · answered by doc 3 · 1⤊ 0⤋
Acetylcholine is a naturally occurring neurotransmitter found in both the peripheral and central nervous systems of many organisms, including humans
2016-03-15 08:58:40 · answer #3 · answered by Anonymous · 0⤊ 0⤋
Are you sure you spelled it right? Did you mean Acetylcholine? I can't find any such spelling /word as you have spelled it.
Acetylcholine was one of the first neurotransmitters to be discovered, (originally called "vagusschtuff" because it was found to be the substance released by stimulation of the vagus nerve that altered heart muscle contractions).
2006-12-18 16:07:18 · answer #4 · answered by That_ blue_ eyed_ Irish_ lass 6 · 0⤊ 0⤋
The chemical compound acetylcholine, often abbreviated as ACh, was the first neurotransmitter to be identified. It is a chemical transmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine is the neurotransmitter in all autonomic ganglia
2006-12-18 16:04:43 · answer #5 · answered by Dwyane 2 · 0⤊ 0⤋
From what i know:
Acetylcholine is a type of neurotransmitter which is part of the body's nervous system. It helps to transmit neural information or impulses from one neuron to another.
2006-12-19 05:48:20 · answer #6 · answered by Ashley 1 · 0⤊ 0⤋
Doesn't anyone on here have google? Look it up yourself.
2006-12-18 15:59:42 · answer #7 · answered by spookykid313 5 · 0⤊ 0⤋