What does grade 1, 2, 3, 4 of the tumor mean in clear cell renal cell carcinoma?

Question

what does each grade mean

Answer 1

Grades refer to how advanced the cancer is. 4 is usually the worst case scenario with metastisies

-- Stages of renal cell cancer --
Once renal cell cancer has been found, more tests will be done to find out if cancer cells have spread to other parts of the body. This is called staging. A doctor needs to know the stage of the disease to plan treatment. The following stages are used for renal cell cancer:

-- Stage I --
Cancer is found only in the kidney.

-- Stage II --
Cancer has spread to the fat around the kidney, but the cancer has not spread beyond this to the capsule that contains the kidney.

-- Stage III --
Cancer has spread to the main blood vessel that carries clean blood from the kidney (renal vein), to the blood vessel that carries blood from the lower part of the body to the heart (inferior vena cava), or to lymph nodes around the kidney. (Lymph nodes are small, bean-shaped structures that are found throughout the body; they produce and store infection-fighting cells.)

-- Stage IV --
Cancer has spread to nearby organs such as the bowel or pancreas or has spread to other places in the body such as the lungs.

-- Recurrent --
Recurrent disease means that the cancer has come back (recurred) after it has been treated. It may come back in the original area or in another part of the body.

Answer 2

Grading is a system that measures the activity and potential of the tumor cells---Gr1=more superficial, completely within the organ of origin...as the cells advance/spread the grading increases.
Gr4=spread of the original tumor cells to other organs and the lymphatic system that generally is called metastasis.
The lower the grade=the better the prognosis if treatment is early.

Answer 3

There r several different staging systems. The most common one is the TNM system. Staging as a 1,2,3,4 is an older system. This site will explain.
http://www.cancer.org/docroot/ETO/content/ETO_1_2X_Staging.asp