pathophysiology of tuberculosis?

Answer 1

Registered Nurse Here; Physiology for Tuberculosis? Tuberculosis is very contiguous during active phase, is spread by droplets via respiratory system. Lesions then form in the lungs, and sometimes are calcified over, if not disease progress, to one is spitting up blood, and breathing and adequate 02 exchange compromised. If left untreated it's fatal. Formerly known as consumption. Was almost eradicated in this country 12 years ago, vaccine discontinued. Rapid increase past 5 to 7 years of TB. This is a very condensed pa-tho of tuberculosis. Would require pages and pages to detail question asked. I do appreciate the opportunity to address such an important question.

Answer 2

okay...bear with me this is kinda long...i hope is what you want...

PATHOPHYSIOLOGY OF TUBERCULOSIS

After exposure to M. tuberculosis, roughly 5% of infected people develop active tuberculosis with 1 year; in the remainder, microorganisms cause a latent infection. Transmission of actice disease is by droplet nuclei prodcude when infected persons sneeze or cough. the host's immune system usually controls the tubercle bacillus by killing it or walling it up in a tny nodule (tubercule). However, the bacillus may lie dormant within the tubercule for years adn later reactivate and spread. Persons with a cavitary legion (large, granulomatous lesion) are particularly infectious because their suptum usually contains 1 million to 100 million bacilli per milliliter. If an inhaled tubercule bacillus settles in an alveolus, infection occurs, with alveolo-capillary dilation and endothelial cell swelling. Alveolitis results, with replication of tubercle bacilli and iflux of polymorphonuclear leukocytes. These organisms spread through the lymph system to the circulatory system and then throughout the body.
Cell-mediated immunity to the mycobacteria, which develops 3 to 6 weeks later, usually contains the infection and arrests the disease. If the infection reactivates, the body's response charcteristically leads to ceseation - the conversion of nercrotic tissue to a cheeslike material. The caseum may localize, undergo fibrosis, or excavate and form cavities, the walls of which are studded with multiplying tubercle bacilli. If this happens, infected caseous debris may spread throughout the lungs by the tracheobronchial tree. Sits of extrapulmonary TB include the pleurae, meninges, joints, lymph nodes, pertoneum, genitourinary tract, and bowel...

Answer 3

see the Merck Manual (now free online)

Also, a good site is:

http://textbookofbacteriology.net/tuberculosis.html