what are statins what do they do and when were they developed?

Answer 1

The statins (or HMG-CoA reductase inhibitors) form a class of hypolipidemic agents, used as pharmaceuticals to lower cholesterol levels in people at risk for cardiovascular disease because of hypercholesterolemia. They work by inhibiting the enzyme HMG-CoA reductase, the enzyme that determines the speed of cholesterol synthesis. Inhibition of this enzyme in the liver stimulates the LDL-receptors, which results in an increased clearance of LDL from the bloodstream and a decrease in blood cholesterol levels. The first results can be seen after one week of use and the effect is maximal after four to six weeks.

Answer 2

Hell yes I did experience the same condition on statins, but after alittle research, even though my CPK test came back negative I started taking CO q 10 it is a supplement. My doctor said a blocked arteries in my legs because I counln't walk 100 feet with out pain, two days of testing and hospital I did not have PAD, so I started the CO Q 10 and after 2 months I could walk furhter withou pain and 6 months later I can walk for miles and exercise. My Dr. finally told me that Statin drugs deplete the the body of this enzyme and He takes 200 mgs daily.

Answer 3

I have no idea when they were developed, but their main function is to lower the level of cholesterol (or lipids) in the blood. Different statin drugs will function in different ways, some inhibiting the production of cholesterol in the liver, and some fascilitating the excretion of cholesterol + bile into the gastro-intestinal track (GIT) system. Examples are Artovastatin, Simvastatin, etc.

Answer 4

Statins are medications that are used to lower cholesterol. They work by inhibiting an enzyme known as HMG-CoA reductase. HMG-CoA reductase is the rate-limiting hepatic enzyme responsible for converting HMG-CoA to mevalonate, a precursor of sterols including cholesterol. Inhibition of HMG-CoA reductase lowers the amount of mevalonate and subsequently reduces cholesterol levels in hepatic cells. This, in turn, results in upregulation of LDL-receptors and increased hepatic uptake of LDL-cholesterol from the circulation. Atorvastatin ultimately reduces the levels of circulating total cholesterol, LDL-cholesterol, and serum triglycerides.
As for when developed I'm not sure around 10 years ago.

Answer 5

Statins are medicines designed to reduce your cholesterol, the normal level for cholesterol is 5.4, I take two different types and mine is a healthy 2.1.

Answer 6

i take 20mg simvastatin daily and my cholestrol is at 3.2 but i have read these tabs can be dangerous however they work for me after heart surgery and a sensible diet of course

Answer 7

Never heard of that one !!!