Is Cleft Lip is Heriditory disorder?

Question

please explain

Answer 1

Risk factors include a family history of cleft lip or palate and presence of another birth defect. The incidence of cleft lip and palate varies with different races. Approximately 1 out of 1,000 Caucasians are affected. The incidence of cleft palate alone is 1 out of 2,500 people.
Please see the webpages for more details and images on Cleft lip and palate

Answer 2

The most common craniofacial malformation identified in the newborn is the orofacial cleft, which consists of cleft lip with or without cleft palate (CL/P) or isolated cleft palate (CP). Although both congenital anomalies result in malformation of the midface, CL/P and CP differ with respect to embryology, etiology, candidate genes, associated abnormalities, and recurrence risk.
Craniofacial development represents a complex interaction of cell patterning, migration, proliferation, and differentiation. Much of facial tissue originates by cell migration from the embryonic neural crest. Underlying this development are regulatory, structural, and positional genes that govern the required cell-cell interactions.
The detection and study of fetal midfacial anomaly has led to important information regarding the candidate genes and environmental factors influencing fetal development.

Genes — The process of midface development involves genes which control cell patterning, cell proliferation, extracellular communication, and differentiation. Gene defects in each of these developmental processes crucial to midface development are associated with cleft malformations. Clefting usually represents a genetically complex event; single Mendelian disorders associated with clefting are rare. While at least one major gene may be operative in one-half of patients, in most cases, 2 to 20 genes are thought to interact to result in facial clefting.
There are several major categories of genetic defects:

Patterning defects, eg, Dlx gene
Proliferation defects, eg, sonic hedgehog gene
Extracellular matrix defects, eg, TGF-alpha variant
Differentiation defects, eg, TGF-beta gene
Interferon regulatory factors, eg, IRF-6
if you need more explanations about each of these genes please contact me, i will tell you more about them.

however we should notice that there are some other known fators, too:
Environmental agents , Medications, Cigarette smoking, Alcohol,...
in summary i can tell you that "yes, cleft lip can be heriditory due to the genes which are responsible in its developing but its somehow a multi-factorial disease and other factors should be mentioned too"

Answer 3

yes i suppose..i have read it some where..cant remember properly..but i ll tell u itz a genetic disorder

Answer 4

Not hereditary.