if a person get infected yeah, wit the hiv virus can it be detected after 4 weeks using teh p24 or antibody?

Answer 1

Hello,

If a person is infected with hiv, the virus starts working and i think antibodies arise.....that is antibody test comes unto play......most people antibody start to flare up within a month of infection where early infection symptoms are evident like Flu symptoms, headache, lesion purple like etc......

An antigen is a part of a virus that stimulates the production of antibodies. Someone who is antibody negative but antigen positive has the virus but has not yet produced antibodies.

The p24 test, this is usually used for screening blood donated by doners for hiv or any other std. Think about it, if the blod is screen once, i honestly don't think they'll tell them to come back in three months time or even lock them up so they don't get busy for take injecting drugs for 3 months or so....

Yes, its true some professionals say that it should be conformatory with a 3 month test, but as explained above they don't keep tight contact with their doners.

It is also correct that the hiv antibody can take months or even years to flare up, this is where p24 or pcr is good, because it looks for the actual hiv virus, which is expensive but beneficary to the patients.

P24 accuracy is also questions, when it's is done too early, that is why pcr is done to detect hiv within 10 days but it is even more expensive than a p24 test.

Some experts say that when infected and the primary symptoms, which might not appear on some patients is 28 days which will show positive for infection, which is on the anitbody test.

p24 picks up because it looks for the actual virus not the anotibody.

To conclude what your question was, Yes it would be detected but earlier in a p24 test than in a antibody test.

In the uk if you wanta p24 privately anyway they perform a p24 test and also an antibody test.

p24 test is 99.8% accuate
antibody test is 99.9% accurate

Take care

Answer 2

I believe that it takes three months for the diease to become detectable in the human blood system. Or it could be that an accurate reading can only be made after 3 months.

Answer 3

It can take months to detect.

Answer 4

Detection of early anti-p24 HIV responses in EIA- and immunoblot-negative individuals. Implications for confirmatory testing.

Vox Sang. 1987;53(1):31-6. Unique Identifier : AIDSLINE MED/88019429
Huisman JG; Winkel IN; Lelie PN; Tersmette M; Goudsmit J; Miedema F; Central Laboratory, Netherlands Red Cross Blood Transfusion; Service.


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Abstract: A sensitive and specific radioimmunoprecipitation assay was developed for the detection and analysis of anti-HIV antibody response in human sera with the use of 125I-labelled purified HIV proteins with subsequent sodium-dodecylsulfate gel electrophoresis (125I-RIPA). The 125I-RIPA was shown to be as specific but at least 1 log more sensitive with respect to the detection of gp41env and p24gag than the immunoblot analysis as tested in serum samples from several risk groups. Sequential sera were obtained from 9 individuals who seroconverted for HIV antibodies. In 4 individuals, antibody to p24gag was detected in earlier serum samples by the 125I-RIPA than by EIA or immunoblot; in the other 5 individuals, the detection of p24gag concorded in enzyme-linked immunosorbent assay (EIA), immunoblot and 125I-RIPA. Moreover, in one of 78 randomly chosen EIA-negative sera from individuals at high risk, antibodies to p24gag could be detected by the 125I-RIPA. This early seroconversion was confirmed 3 months later by means of immunoblotting and EIA. The specificity of the 125I-RIPA was further demonstrated by analyzing sequential EIA-negative serum samples from 10 individuals at risk for AIDS, collected during 2 years at 3-monthly intervals. All 80 serum samples were found to be negative in the 125I-RIPA and the individuals revealed no signs of HIV infection. The 125I-RIPA technique may be a valuable confirmatory assay in the serology of HIV infections. The sensitivity of this test provides a reliable measure of effective sensitivity when new-generation screening tests are evaluated.(ABSTRACT TRUNCATED AT 250 WORDS)
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Keywords: Acquired Immunodeficiency Syndrome/DIAGNOSIS Antibodies, Viral/*ANALYSIS *Enzyme-Linked Immunosorbent Assay False Positive Reactions Human HIV/*IMMUNOLOGY/METABOLISM *Immunologic Techniques Iodine Radioisotopes/DIAGNOSTIC USE Male Precipitation Radioimmunoassay/*METHODS Time Factors Viral Proteins/ANALYSIS JOURNAL ARTICLE


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M8810147


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Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is made possible through unrestricted grants from Boehringer Ingelheim, iMetrikus, Inc., the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 1988. This material is designed to support, not replace, the relationship that exists between you and your doctor.

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Copyright ©1980, 1988. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. [e-mail].

Answer 5

Here is some info. on dectection and testing of HIV. Please also check out the website that I pasted below in Sources. Best of luck to you & Take Care :)

Detection of HIV Infection: Diagnostic Testing
Testing for HIV is recommended and should be offered to all persons who seek evaluation and treatment for STDs. Counseling before and after testing (i.e., pretest and posttest counseling) is an integral part of the testing procedure (see HIV Prevention Counseling). Informed consent must be obtained before an HIV test is performed. Some states require written consent.

HIV infection usually is diagnosed by tests for antibodies against HIV-1 and HIV-2 (HIV-1/2). Antibody testing begins with a sensitive screening test (e.g., the enzyme immunoassay [EIA]). Reactive screening tests must be confirmed by supplemental test (e.g., the Western blot [WB]) or an immunofluorescence assay (IFA). If confirmed by a supplemental test, a positive antibody test result indicates that a person is infected with HIV and is capable of transmitting the virus to others. HIV antibody is detectable in at least 95% of patients within 3 months after infection. Although a negative antibody test result usually indicates that a person is not infected, antibody tests cannot exclude recent infection.

Most HIV infections in the United States are caused by HIV-1; <100 cases of HIV-2 infection have been documented (22). However, HIV-2 infection should be suspected in persons who have epidemiologic risk factors for HIV-2. Examples of these risk factors include persons with sex partners from West Africa (where HIV-2 is endemic), those with sex partners known to be infected with HIV-2, and persons who received a blood transfusion or a non-sterile injection in a West African country. HIV-2 testing is also indicated when clinical evidence of HIV exists but tests for antibodies to HIV-1 are not positive, or when HIV-1 Western blot results include the unusual indeterminate pattern of gag plus pol bands in the absence of env bands (22).

Health-care providers should be knowledgeable about the symptoms and signs of acute retroviral syndrome, which is characterized by fever, malaise, lymphadenopathy, and skin rash. This syndrome frequently occurs in the first few weeks after HIV infection, before antibody test results become positive. Suspicion of acute retroviral syndrome should prompt nucleic acid testing (HIV plasma RNA [i.e., viral load]) to detect the presence of HIV, although this test is not approved for diagnostic purposes; a positive test should be confirmed by another HIV test. Current guidelines suggest that persons with recently acquired HIV infection might benefit from antiretroviral drugs, and such patients may be candidates for clinical trials (23,24). Therefore, patients with acute HIV infection should be referred immediately to an HIV clinical care provider.

Detection of HIV infection should prompt efforts to reduce the risk behavior that resulted in HIV infection and could result in transmission of HIV to others. Early counseling and education are particularly important for persons with recently acquired infection, because HIV plasma RNA levels are characteristically high during this phase of infection and likely constitute a risk factor for HIV transmission.

The following are specific recommendations for diagnostic testing for HIV infection.

HIV testing is recommended and should be offered to all persons who seek evaluation and treatment for STDs.
Informed consent must be obtained before an HIV test is performed; some states require written consent.
Positive screening tests for HIV antibody must be confirmed by a more specific confirmatory test (either WB or IFA) before being considered diagnostic of HIV infection.
Patients who have positive HIV test results must receive initial counseling on-site and should either a) receive behavioral, psychosocial, and medical evaluation and monitoring services or b) be referred for these services.
Providers should be alert to the possibility of acute retroviral syndrome and should perform nucleic acid testing for HIV, if indicated. Patients suspected of having recently acquired HIV infection should be referred for immediate consultation with a specialist.