why plasmapheresis is use to remove factor VIII,could this be use in a procoagulable state?

Answer 1

The process of plasma pheresis is similar to dialysis. The blood is removed and the blood components separated and all of the components are returned to the donor except plasma. Once the plasma is removed from the donor it is processed to remove only the Factor VIII. It takes the blood of many donors to make Factor VIII products. Now a common way to make Factor VIII is with recombinant DNA - reducing the risk to the recipient of blood borne diseases.
It is possible to use plasma pheresis to remove some abnormal proteins from a patient - like someone with Multiple Myeloma - but to use this to reduce the amount of Factor VIII because they have a procoagulable state would not be very practical. There are a lot more treatments and options - Heparin, Coumadin, Aspirin, Plavix.

Answer 2

it's used for people that have bleeding disorders such as hemophilia.