why is the ejection fraction of an b blocker treated patient reduced?

Question

do b blocker produce reaction to the endotelial membrane phospholilpid,huge syndrome,can you define completely the "Huge" syndrome anti phospholipid membrane inmune reaction

Answer 1

A b-blocker despite being a negative ionatrope can increase ejection fraction over time. A particular b-blocker has been shown to be especially effective for this purpose - Coreg which has both alpha and beta blocking properties can be very useful in improving ejection fraction over time. Because b-blockers work on the SA node and slow the the number of heart contractions in a minute, it allows for adequate filling and a more robust pump and is useful in helping the heart to remodel in a productive way.

I searched Pub Med (all major worldwide scientific journals for the last 20 years) with no results on "huge syndrome." Therefore what ever it is, it has never been published in a respected journal.

Good luck.

Answer 2

Ejection fraction (E.F.), by definition, is the amount of blood that is pumped out of the heart with each contraction (beat) relative to the amount of blood that was present before the contraction began. Think of a bellows filled with air and then grab the belly of it with a fist. A lot of air will pump out but some will remain. The amount that pumped out is the ejection fraction. The example uses arbitrary numbers:

Amt. of blood before beat- Amt. after
----------------------------------------------------...--------= E. F.
Amount of blood before beat

100 mls - 30mls
-----------------------=E.F. of 70%
100 mls

Ejection fraction is measured in percent. Normal E.F. is about 67%. Higher than that is suggestive of a problem ( a leaky regurgitant valve) and a lower value (below 50%) is also suggestive of a problem (heart failure, coronary artery disease, cardiomyopathy).

One of the determinants of ejection fraction is how hard the heart muscle squeezes (called inotropy) and thus how much blood is ejected from it. Just like with the bellows, the harder you squeeze the more air comes out and vice versa.

B-blockers reduce the ejection fraction because one of their properties is as a 'negative inotrope' meaning they force the heart to squeeze less forcefully and vigorously thereby requiring the muscle itself to not work as hard and thus require less oxygen (i.e. less blood flow). Think of it as a child squeezing the bellows rather than an adult.

I have not heard of "Huge" syndrome. Sorry I can't help you with that part of your question.

Answer 3

yeah ive never heard of huge symptom either. basically how they work is they block beta1 receptors which are the adrenergic control (you have 2 systems that control the heart, adrenergic system increases heart's contraction force and speed, cholinergic stimulation decreases it) which blocks adrenergic stimulation, does some stuff with cGMP (i think, maybe its something else) and eventually decreases calcium flow in the heart cells which slows the heart down and makes the contractions weaker