ibuprofen overdose?

Question

I had a headache that lasted for while, and now that i think of it, it wasn't that bad of a head ache at all. Anyways, I took 1000mg of ibuprofen withing 2 hours, and i realized the bottle had said take smallest amount of dosage, which is eather one, two--only if pain persist, every 4-6 hours. (There are 200mg in each pill.) I feel incredibly tired and my legs feel weak. How damaging is this?

I weigh 104 lbs

Also, in the past, not too long ago I had taken four pills of tylenal sleep medication. I think they may have had 200mg or less in them, and my body reacted by throwing up several hours later, several times. Would this mean that my body would react even worse to five pills of ibuprofen?

Answer 1

Ibuprofen overdose has become common since it was licensed for over-the-counter use. There are many overdose experiences reported in the medical literature. Human response in cases of overdose ranges from absence of symptoms to fatal outcome in spite of intensive care treatment. Most symptoms are an excess of the pharmacological action of ibuprofen and include abdominal pain, nausea, vomiting, drowsiness, dizziness, headache, tinnitus, and nystagmus. Rarely more severe symptoms such as gastrointestinal bleeding, seizures, metabolic acidosis, hyperkalaemia, hypotension, bradycardia, tachycardia, atrial fibrillation, coma, hepatic dysfunction, acute renal failure, cyanosis, respiratory depression, and cardiac arrest have been reported. The severity of symptoms varies with the ingested dose and the time elapsed, however, individual sensitivity also plays an important role. Generally, the symptoms observed with an overdose of ibuprofen are similar to the symptoms caused by overdoses of other NSAIDs.

There is little correlation between severity of symptoms and measured ibuprofen plasma levels. Toxic effects are unlikely at doses below 100 mg/kg but can be severe above 400 mg/kg; however, large doses do not indicate that the clinical course is likely to be lethal. It is not possible to determine a precise lethal dose, as this may vary with age, weight, and concomitant diseases of the individual patient.

Therapy is largely symptomatic. In cases presenting early, gastric decontamination is recommended. This is achieved using activated charcoal; charcoal absorbs the drug before it can enter the systemic circulation. Gastric lavage is now rarely used, but can be considered if the amount ingested is potentially life threatening and it can be performed within 60 minutes of ingestion. Emesis is not recommended. The majority of ibuprofen ingestions produce only mild effects and the management of overdose is straightforward. Standard measures to maintain normal urine output should be instituted and renal function monitored. Since ibuprofen has acidic properties and is also excreted in the urine, forced alkaline diuresis is theoretically beneficial. However, due to the fact ibuprofen is highly protein bound in the blood, there is minimal renal excretion of unchanged drug. Forced alkaline diuresis is therefore of limited benefit. Symptomatic therapy for hypotension, GI bleeding, acidosis, and renal toxicity may be indicated. Occasionally, close monitoring in an intensive care unit for several days is necessary. If a patient survives the acute intoxication, he/she will usually experience no late sequelae.-

Answer 2

1

Answer 3

Ibuprofen Toxicity

Answer 4

Usually an ibuprofen overdose would make your stomach hurt and you would possibly vomit. Maybe you're just coming down with something.

How much do you weigh because sometimes doctors prescribe 1000mg of ibuprofen for injuries and people don't overdose off of it. Unless you are tiny. Just drink lots of water and eat something. If you are really worried and your symptoms get worse, call the doctor.

Answer 5

This Site Might Help You.

RE:
ibuprofen overdose?
I had a headache that lasted for while, and now that i think of it, it wasn't that bad of a head ache at all. Anyways, I took 1000mg of ibuprofen withing 2 hours, and i realized the bottle had said take smallest amount of dosage, which is eather one, two--only if pain persist, every 4-6 hours....

Answer 6

Based on your weight, 1000 mg was probably way too much, but hopefully not serious. I weigh 140ish and I take up to 800mg at a time from doctor's orders. Side effects of taking a lot of ibuprofen are drowsiness and, if you took it on an empty stomach, heartburn and possibly stomach bleeding.

If you feel really awful, you should call poison control and see what they say.

Answer 7

It's very unlikely that you overdosed. My mom's a nurse, so I've learned a lot from her. In a hospital, they generally give you 800 milligrams of ibuprofin. I highly doubt one extra pill is enough to give you the symptoms you're complaining of. And also, tylenol is a brand of acetimenophin, so it's not the same thing as ibuprofin, and so, the two wouldn't affect one another. If I were you, I wouldn't worry too much. You probably just have some sort of bug. It should pass.
Hope you get to feeling better!

Answer 8

In short, you just thinned out your blood really really well for a period of time and make this a learning experience.
Read below the max recommended dosage and the side affects of ibuprofen.

Next time, please, please, please, read the label when taking an over the counter med. Many people falsely believe that because you can buy it in a store, the drug is safe to take without reading the label. I'm a nurse, and when I give a med that I'm not familiar with, I look it up before giving it to a patient.


The following is from:
http://www.medicinenet.com/ibuprofen/article.htm
"When under the care of a physician, the maximum dose of ibuprofen is 3.2 g daily (that's 3,200 mg in a 24 hour period). Otherwise, the maximum dose is 1.2 g daily (1,200 mg)"
"SIDE EFFECTS: The most common side effects from ibuprofen are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation and heartburn. NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Ibuprofen may cause ulceration of the stomach or intestine, and the ulcers may bleed. Sometimes, ulceration can occur without abdominal pain, and black, tarry stools, weakness, and dizziness upon standing (orthostatic hypotension) due to bleeding may be the only signs of an ulcer. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients who already have impaired function of the kidney or congestive heart failure, and use of NSAIDs in these patients should be cautious. People who are allergic to other NSAIDs, including aspirin, should not use ibuprofen. Individuals with asthma are more likely to experience allergic reactions to ibuprofen and other NSAIDs. Fluid retention (edema), blood clots, heart attacks, hypertension and heart failure have also been associated with the use of NSAIDs. "

Wikipedia has a good explaination on human toxicology
http://en.wikipedia.org/wiki/Ibuprofen#Human_toxicology

Ibuprofen overdose has become common since it was licensed for over-the-counter use. There are many overdose experiences reported in the medical literature.[12] Human response in cases of overdose ranges from absence of symptoms to fatal outcome in spite of intensive care treatment. Most symptoms are an excess of the pharmacological action of ibuprofen and include abdominal pain, nausea, vomiting, drowsiness, dizziness, headache, tinnitus, and nystagmus. Rarely more severe symptoms such as gastrointestinal bleeding, seizures, metabolic acidosis, hyperkalaemia, hypotension, bradycardia, tachycardia, atrial fibrillation, coma, hepatic dysfunction, acute renal failure, cyanosis, respiratory depression, and cardiac arrest have been reported.[13] The severity of symptoms varies with the ingested dose and the time elapsed, however, individual sensitivity also plays an important role. Generally, the symptoms observed with an overdose of ibuprofen are similar to the symptoms caused by overdoses of other NSAIDs.

There is little correlation between severity of symptoms and measured ibuprofen plasma levels. Toxic effects are unlikely at doses below 100 mg/kg but can be severe above 400 mg/kg;[14] however, large doses do not indicate that the clinical course is likely to be lethal.[15] It is not possible to determine a precise lethal dose, as this may vary with age, weight, and concomitant diseases of the individual patient.

Therapy is largely symptomatic. In cases presenting early, gastric decontamination is recommended. This is achieved using activated charcoal; charcoal absorbs the drug before it can enter the systemic circulation. Gastric lavage is now rarely used, but can be considered if the amount ingested is potentially life threatening and it can be performed within 60 minutes of ingestion. Emesis is not recommended.[16] The majority of ibuprofen ingestions produce only mild effects and the management of overdose is straightforward. Standard measures to maintain normal urine output should be instituted and renal function monitored.[14] Since ibuprofen has acidic properties and is also excreted in the urine, forced alkaline diuresis is theoretically beneficial. However, due to the fact ibuprofen is highly protein bound in the blood, there is minimal renal excretion of unchanged drug. Forced alkaline diuresis is therefore of limited benefit.[17] Symptomatic therapy for hypotension, GI bleeding, acidosis, and renal toxicity may be indicated. Occasionally, close monitoring in an intensive care unit for several days is necessary. If a patient survives the acute intoxication, he/she will usually experience no late sequelae.

Answer 9

The dose suggestions on the label are there for safe dosages for the average person. 250 or 350 mg once or twice every 4-6 hours is a dose that your body particularly the liver is able to detoxify. It will then be excreted in your urine. People who overdose on overthe counter medications in large dosages risk damaging their liver or at least imparing its function. People with poor liver function must minimize the amt taken or avoid completely. Teenagers who overdose on over the counter drugs may not realize that they may live but will have a damaged liver for the rest of there lives. Those who are following the pacackging guideline have little to fear unless they have an existing liver or kidney damage.

Answer 10

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