How do dermal patches relase their medication into our bodies? What does solubility have to do with it?

Answer 1

Great question... The medication has to be suspended within the adhesive layer on the patch. This adhesive layer is in contact with the skin and the moisture from the skin acts as the transferring agent between the adhesive layer on the patch and the capillaries within your skin.

The moisture in your skin dissolves the medication in the adhesive layer. To do that, the medication has to be soluble in water. Because the concentration is greater in the adhesive layer, it travels to the lesser-concentrated area and dissolves into the sweaty moisture... From there it is transferred to your blood stream, again by the greater-to-lesser concentration principle, and then goes throughout your body after being absorbed through capillaries.

The medication has to be both soluble in the adhesive as well as in the water in your skin and blood.

Answer 2

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RE:
How do dermal patches relase their medication into our bodies? What does solubility have to do with it?

Answer 3

Some drugs are delivered bodywide through a patch on the skin. These drugs, sometimes mixed with a chemical (such as alcohol) that enhances penetration of the skin, pass through the skin to the bloodstream without injection. Through a patch, the drug can be delivered slowly and continuously for many hours or days or even longer. As a result, levels of a drug in the blood can be kept relatively constant. Patches are particular useful for drugs that are quickly eliminated from the body, because such drugs, if taken in other forms, would have to be taken frequently. However, patches may irritate the skin of some people. In addition, patches are limited by how quickly the drug can penetrate the skin. Only drugs to be given in relatively small daily doses can be given through patches.

Absorption via the transdermal route primarily occurs by passive diffusion. The rate of diffusion is governed by the properties described in Fick’s Law of Diffusion. This law describes the interactions of several factors, including the diffusion coefficient of the drug, the partition coefficient of the drug, the concentration of the drug applied, the surface area of the skin over which the drug is applied, and the thickness of the epidermis itself.

SOLUBILITY is an ability of a substance to dissolve. In the process of dissolving, the substance which is being dissolved is called a solute and the substance in which the solute is dissolved is called a solvent. A mixture of solute and solvent is called a solution.

In your case,lets apply the solubility property in the trans dermal patch function.
The solute would be the contents of the patch; alcohol is the solvent that increases its absorption,while the mixture produced by the two components would be the by product drug itself.


Hope that helps!!!

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Answer 4

Dermal patches release their medication by transdermal migration from a patch placed on the outer surface of the skin.

Patches with the medications enclosed have the medication permeate out of the patch reservoir and into and through the skin. Delivery of the medication is limited by the rate of passage of the medication through the patch membrane to the skin.

Patches with medications enclosed and absorption enhancer cream outside the patch are directly in contact with the skin and the medication needs only to separate from the cream in order to be available for transdermal migration.

Medications absorbed transdermally bypass the gastrointestinal tract and first-pass metabolism by the liver. With that, significant amounts of medication are not eliminated from the body before the medication reaches the target tissues.

Solubility has a great impact on the absorption of medication from patches. That is the main purpose of those absorption enhancers which had been incorporated in medicated patches. Absorption enhancers are aimed at solubilizing a medication capable of being administered transdermally. Thus an improvement of diffusion of the medication into and within the patient's skin is expected.

Answer 5

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The capillaries that are near the surface of the skin known as the epidermis will absorb the medications that are put through these patches that would be able to go to the blood stream. I hope that this helps you.