Why should human RBC's be enucleated?

Question

what advantages do RBC get by losing their nucleus?

Answer 1

because the main function of the RBC's is to carry oxygen to all body tissues from the lung and the vise versa with the carbon dioxide...
so the structure of the RBC should accomodate to its function as follow:
-there's no nucleus to provide more space to carry large amounts or oxygen.
-also,it has a biconcave shape to increase its surface area and help it carry the largest amounts of oxygen possible....

Answer 2

Red cells are designed for only a finite life span - usually 120 days in a normal state. During that time they travel an estimated 300 miles and make 170,000 trips through the heart and circulatory system. They do not have the ability to renew structural proteins and critical enzymes, so they are meant to be broken down with the materials re-utilized in new RBC's - we make or 'release' an estimated two million per second. We each have about 20-30 trillion red blood cells. (They're fun to look at under the microscope.)
Also, they have to be highly deformable to get through the capillary circulation 170,000 times. A nucleus would get in the way. They are just nice, neat bags of hemoglobin.

Answer 3

The above are good answers. I would add one more thing. Nuclei are the sites of huge amount of cellular activity, which consumes large amount of energy. It is advantageous for RBCs not to have a nucleus, so they provide the maximum oxygen to the tissues and do not use it up themselves. As you know, RBC precursosors in the bone marrow are "born" with a nucleus and loose it along the way. Good question, btw.