How does Sickle cell give people an advantage against malaria?

Question

Please include these key words
base pairs
Mutation
Amino acids

Answer 1

The precise mechanism by which sickle cell trait imparts resistance to malaria is unknown.
>>Sickle hemoglobin which makes a change in the hemoglobin molecule possibly impairs malaria growth and development.
>>A low oxygen tension in the cells may not be suitable for malaria parasite growth.
>>As red cells are constantly created and destroyed as part of their life cycle, a mutation that somehow destroys both the infected red cells and the parasite could possibly eliminate the malaria parasite.