Over 35 percocet - no significant effects?

Question

So I had this weird occurrence a few weeks ago- I took 35 percocet (5 mg oxycodone, 350 mg of acetaminophen per tablet) and well nada happened. Literally (well aside of passing out and vomiting all night and the next day).

This thing puzzles me a lot , I read that 10 mg of acetaminophen is supposed to cause damage to the liver, yet it apparently did not .
How is this possible? -Can pharmacokynetics vary that much ? I am 180 lbs and generally healthy (exercise a lot, follow healthy diet, do not drink at all) but it was over 13 g for christ sakes.

I seem to have high tolerances to some medication (namely for example I can take over 10 mg of ativan and not pass out -I will be quite sleepy, but generally can function) , -I was told that some people pass out from as little ast 1.5 mg.

Can it be some sort of disorder?

Hey well it is not about that I took it (that is over and done).

This is just freaking puzzles me - and yeah I went to ER next day as I freaked out about it ( I was counting on respiratory arrest from oxycodone, not liver damage ) so I thought since it did not work I do not want to die from liver damage. Anyway the fact is that I got admitted and released after 3 days - with no liver damage whatsoever. Mind you it passed over 8 hours after ingestion and trip to ER, so it had to be absorbed.

And the tablets itself -they seemed to be working fine (well you get a little high if you take it -that is how I tell :) ) and I doubt that those drugs expire after a year anyways.

I researched quite a bit and seemed that 10g+ seems to be the toxic dose.
So well I am interested in how much pharmacokinetics can vary - maybe high tolerances to some thing is just relatively common occurrence

Answer 1

From a pharmokinetic/pharmacology point of view i would ask what you weigh, how tall you are, male or female (i take it male), your diet, and any other drugs you may have been taking in recent days, weeks, etc, how much water did you drink or eat with this dosage, over how long of a period did you take the drug, Do you smoke, you drink, do you eat alot of charcoled food, your age, ethnic background, etc....... all of these may influence your biochemistry, most importnatly your P450 enzymes which are a major player in drug metabolism as well as other enzymes in the liver.

Presumably you did not take all 35 at once, the acetometaphen toxicity alone would probably put you into shock, the only explaination i might offer you is that you pocess a very fast Phase 1 and or Phase 2 drug metabolism, which is just a grouping of metabolic pathways and excretion modifications that your body does to drugs.

the fact you did vomit may have gotten rid of alot of the drug, you passed out which tells me you may have atleast some hyptnotic response to the analgesic. 5mg x 35 = 175mg, now to put that in perspective they do perscribe oxycontins at the 80 and 160 mg range, and i ahve known of people who take 2-3 of the 80's a day for pain, however they have already built tolerance. I think you may have some scaring on the liver due to the acetominophen toxicity, and that scaring probably wont affect you for some time but may in the future.

Granted i am still hesitant to your claim, but if it is true i would be curious if maybe you have a combined elevated drug metabolism/excretion pathway and a mutated opioid receptor that is unable to recognize exogenous opiates. Other than that i call BS on the story...... Good luck with the medical oddity and cudos to the independent research.

Answer 2

You are correct - it is amazing that you got away with this.
A one time overdose with 12.25 grams of acetaminophen could have led to irreversible liver damage which is a nasty way to go.
You have been very, very lucky. If you ingested alcohol with the Percocet, the risk of liver damage would have been even greater. Do not risk this again. I've seen people die this way and it is not quick or comfortable.
People vary a great deal, so you can't say what the lethal does will be for each person. It is not a disorder.

Answer 3

Realize there is a big difference in acute and chronic.
I'm not sure where you read that about acetaminophen, but hey have been tlaking about long term effects of taking the stuff, every day, for years. Then the problem will likely be too late to do anything about.

Answer 4

First of all the liver damage is over time with acetaminophen, not just a one time thing. Next that's a lot of painkillers, slow down buddy.

Answer 5

How do you know your liver was not damaged? Did you go to the ER and have it checked? Your playing a dangerous game and frankly, someday your gonna lose... your life.

Answer 6

Try more...perhaps 75 tablets might get you where ever it is you are trying to go.

Answer 7

You sound lovely... Want a date?