Why does timentin cause increase Na/sodium, and Decrease K/Potassium?

Question

Cant work it out... Heres a site on the drug, in case you know it by another name/etc.

http://en.wikipedia.org/wiki/Timentin

thanks in advance for any help!

Answer 1

It isn't at all complicated. The commercially available ticarcillin is ticarcillin sodium, the sodium salt. It's simply a matter of infusing sodium as part of the solution. Sometimes we just think too hard.

Answer 2

Triamterene not Tricarcillin directly blocks the epithelial sodium channel (ENaC) on the lumen side of the kidney collecting tubule. Other diuretics cause an increase in the sodium concentrations in the forming urine causing more sodium to enter through ENaC, chasing more potassium out of the principal cell and into the forming urine. Blocking ENaC prevents this from happening.
So it is given in combinationwith other diuretics like Thiazides

Answer 3

the word is Triamterene, it directly blocks the epithelial sodium channel (ENaC) on the lumen side of the kidney collecting tubule. Other diuretics cause an increase in the sodium concentrations in the forming urine causing more sodium to enter through ENaC, chasing more potassium out of the principal cell and into the forming urine.

Blocking ENaC prevents this from happening.