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Low platelet count is frequently assumed to represent ITP (immune thrombocytopenic purpura). However there are many other possible causes of thrombocytopenia, with clinical severity ranging from trivial to life threatening. ITP is a diagnosis of exclusion. This means that only after all other possible causes of low platelets have been ruled out, can a diagnosis of ITP be settled.


This makes it important to know or at least be aware of the other common causes of low platelets that may be mistaken for or misdiagnosed as ITP. These other causes are either platelet production problems centered in the bone marrow or platelet destruction problems centered in the liver or spleen. Some low platelet conditions are characterized by both a low rate of production and a high rate of platelet destruction. The most common conditions or defects responsible for low platelets are listed in the following categories.

I. Platelet Production Problems
A. Inherited
B. Non-inherited


II. Platelet Destruction Problems
A. Immune Mediated
B. Non-immune Mediated


Some of the diseases and conditions listed could be included in several of these categories. Autoimmune Lymphoproliferative Syndrome (ALPS) is an example; it is both inherited and immune-mediated. This brief review covers the most frequent causes of thrombocytopenia but is not meant to be comprehensive. Distinguishing ITP from other conditions is usually done clinically, paying careful attention to the onset of symptoms, family history, medication use, and recent illnesses. When thrombocytopenia is severe (i.e. platelet count less than 20-30,000/microliter), a trial of immunosuppression is generally administered (prednisone, anti-D, IVIG). A rapid response (within a week) to these therapies helps confirm the diagnosis as ITP. Failure to respond should lead to further investigation of alternate causes.

2007-10-14 19:25:24 · answer #1 · answered by rosieC 7 · 0 0

These factors contribute to high blood platelets:

1. Change your perception of time. Don't be in a hurry.
2. Get restful sleep.
3. Eat fresh, nutritious food.
4. Take at least two multivitamins with minerals every day.
5. Practice a mind body technique such as yoga or tai chi.
6. Exercise regularly.
7. Don't put toxins in your life, including toxic food, toxic
emotions, toxic relationships, and avoid toxic environments or toxic relationships.
8. Have a flexible attitude to minor hassles.
9. Look at so-called problems as opportunities.
10. Nurture loving relationships.
11. Always have an attitude of curiosity, learning, and wonder and spend time with children.

So, if you're seeking a lower platelet count...do just the opposites!
.

2007-10-14 18:26:00 · answer #2 · answered by AlmondJoey 2 · 0 0

Thrombocytopenia (low platelet count) can be caused by many conditions among them:

Pregnancy, which may cause mild thrombocytopenia.

Idiopathic thrombocytopenic purpura (ITP), a condition in which your immune system mistakenly identifies platelets as a threat and forms antibodies that attack them.

Other autoimmune diseases, such as lupus and rheumatoid arthritis, which may lead to destruction of platelets due to a malfunctioning immune system.

Blood poisoning (septicemia) from severe bacterial infections, which may lead to destruction of platelets.

Thrombotic thrombocytopenic purpura (TTP), a rare, life-threatening condition that occurs when small blood clots suddenly form throughout your body, using up large numbers of platelets. TTP can happen sporadically or as a side effect of some medications.

Hemolytic uremic syndrome, another rare disorder that causes a sharp drop in platelets, destruction of red blood cells and impairment of kidney function. Sometimes, this can occur in association with a bacterial Escherichia coli (E. coli) infection, such as may be acquired from eating raw or undercooked meat (often hamburger).

Thrombotic thrombocytopenic purpura

Drug-induced thrombocytopenia, e.g. heparin-induced

Gaucher's disease

Aplastic anemia

Alloimmune disorders

Fetomaternal alloimmune thrombocytopenia

Some transfusion reactions

Disorders leading to platelet dysfunction or reduced count:

HELLP syndrome
Hemolytic-uremic syndrome
Chemotherapy
Dengue

And the list goes on, look at the references for additional information.

2007-10-14 18:53:43 · answer #3 · answered by HANAN. 3 · 0 0

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