Cervical cancer is one of the most common cancers that affect a woman's reproductive organs. Various strains of the human papillomavirus (HPV), a sexually transmitted infection, play a role in causing most cases of cervical cancer.
When exposed to HPV, a woman's immune system typically prevents the virus from doing harm. In a small group of women, however, the virus survives for years before it eventually converts some cells on the surface of the cervix into cancer cells. Half of cervical cancer cases occur in women between ages 35 and 55.
Causes-
In general, cancer begins when healthy cells acquire a genetic mutation that turns normal cells into abnormal cells. Healthy cells grow and multiply at a set rate, eventually dying at a set time. Cancer cells grow and multiply out of control, and they don't die. The accumulating abnormal cells form a mass (tumor). Cancer cells invade nearby tissues and can break off from an initial tumor to spread elsewhere in the body (metastasize).
Cervical cancer most commonly begins in the thin, flat cells that line the bottom of the cervix (squamous cells). Squamous cell carcinomas account for about 80 percent of cervical cancers. Cervical cancer can also occur in the glandular cells that line the upper portion of the cervix. Called adenocarcinomas, these cancers make up about 15 percent of cervical cancers. Sometimes both types of cells are involved in cervical cancer. Very rare cancers can occur in other cells in the cervix.
Hereditary is another reason people get this disease-
And of course as you now the Genital Warts appearing due to HPV is also a main cause-
2007-10-02 19:41:50
·
answer #1
·
answered by Jayaraman 7
·
1⤊
0⤋
It is important to realize that cancers of any sort can be inherited, sporadic (due to environment), and infection (viral insertion being the common cause).
In the case of inherited cancers there is a very very small percent chance you have this. This means that you inherited it through your germline cells (mother's egg or father's sperm). But these cancers are more commonly found in Breast and Prostatic Cancers (at which point they aren't even common to those cancers - meaning the sporadic breast and prostate cancers are 95% more likely to occur).
In the case of sporadic, teratogens or mutagens may be involved. Most cancers are due to an abnormality involving the p53 protein. This protein has many functions but you should know that it is vital to the cell. Other proteins like Her2, Neu (erbB2), cdk1 and 2 etc, ras, raf, and the list goes on can be involved in cancers too. It is not too say that an inherited form of cancer that involves these proteins don't occur, because they can . . . but again very unlikely. It is the case, though, where you develop cancers mostly because there is a mutation in your genes.
In regards to cervical cancers here are some of the common causes:
HPV (human papiloma virus) is now accepted as the MAIN CAUSE in cervical cancer and preinvasive epithelial lesions. Approx. 100 types of HPV have been identified. Approx. 20 HPV subtypes infect the cervix. HPV subtypes with a high risk of malignant transformation of the cervical epithelium include subtypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, and 58. HPV subtypes with a low risk of malignant transformation of the cervical epithelium include subtypes 6, 11, 42, 43, and 44.
Intrinsic immunologic response must be an additional factor since most patients infected with HPV do not continue to show evidence of infection.
Other contributory or predisposing factors:
HIV and other immunodeficiencies: cervical dysplasia is associated with more rapid progression and higher recurrence rates in HIV-positive women than in HIV-negative women.
Smoking may also act as an independent risk factor by altering the cellular metabolism of the cervix.
Diethylstilbestrol (DES) exposure in utero.
More sites are therefore at risk of malignant transformation in the presence of HPV.
DES was used in the US between 1938-71; therefore, it is not a concern for patients born after 1971.
Associated with high-risk sexual behavior such as early age at onset of sexual activity, multiple partners, and contraction of other sexually transmitted diseases
Risk is increased for sexual partners of men whose previous partner had cervical cancer
2007-10-02 19:39:23
·
answer #2
·
answered by Jack B 2
·
0⤊
0⤋
Yes, certainly. Treating the inflamed cells does no longer do away with the virus, similar to blowing your nostril if in case you have a bloodless does no longer get the bloodless virus from your frame. HPV has a existence span of nine months to 2 years, so if it's been 2 years or much less due to the fact he left her, you would have HPV. Just be definite you keep up-to-date in your paps so that you could seize any irregular cervical cells faster instead than later. And do not fear an excessive amount of; simply considering that the virus reacted and prompted irregular cells for her does no longer imply it's going to for you.
2016-09-05 15:52:21
·
answer #3
·
answered by ? 4
·
0⤊
0⤋
I believe cancer, by it's nature, is just cells growing out of control, so it appears that anyone could potentially end up having cervical cancer, but yes, HPV does increase the chances if you have the "right" strain.
2007-10-02 19:21:52
·
answer #4
·
answered by Super_Star 2
·
0⤊
0⤋
All of the reasons are unknown. My mother has been diagnosed with it and to this day they don't know where it came from. She didn't get it from HPV nor warts. And in speaking with her oncologist, it is NOT hereditary.
2007-10-04 21:21:46
·
answer #5
·
answered by Anonymous 4
·
0⤊
0⤋
By far, the majority of cases are due to HPV. However, just like any cancer, anyone can possibly get it.
2007-10-02 19:31:14
·
answer #6
·
answered by Alex 2
·
0⤊
0⤋
I have heard most women carry the gene, but really don't know why sometimes it turns into full cervical cancer.
2007-10-02 19:31:25
·
answer #7
·
answered by keri f 2
·
0⤊
0⤋
They say it can be hereditary
2007-10-02 19:21:19
·
answer #8
·
answered by Rev.Michelle 6
·
0⤊
0⤋
heredity
2007-10-02 19:22:21
·
answer #9
·
answered by katie d 6
·
0⤊
0⤋