Where are the weak points on a Ford 460 ("385" series) to upgrade?

Question

I have a Ford 460 in running condition, and a pair of Schwitzer turbos to go onto it eventually. I also have an Edelbrock performer intake manifold for a 390FE, and matching headers, that might fit this?. I plan to arrange the turbos to feed a 650CFM Holley in blow-thru setup, and run MSD-6AL ignition off the stock distributor's inductive pickup. I will use a high performance electric fuel pump, and a boost-compensating regulator, to ensure consistent fuel delivery.

I plan to lower the compression either with .125" copper head gaskets, or dished forged pistons, either are 30cc changes to get 8:1 compression. I want to run an appropriate amount of boost, but not into the range of gambling with wrecking the engine.

For those experienced with the 460, what are its flaws and vulnerable parts? What parts need to upgrade, which are good enough from factory? I don't plan on boosting more than maybe %15 on horsepower.

This is going in a 4x4 F250 with a C6 Automatic and Dana 60s

Answer 1

there are a couple of good groups that can guide you..

http://autos.groups.yahoo.com/group/turbo
http://autos.groups.yahoo.com/group/jyturbo

Answer 2

Nothing from the 390 FE will fit the 460.
Dropping the compression with a head gasket will give you weak point.
Raising the heads 0.125 also will require thicker intake gasket to align the ports and this will offer another weak point. (especially with supercharging).
I would recommend the lower pistons.
Twin turbos work better with twin carbs.
Old Fart Ford Racer