I know I can't give blood, but was curious whether or not it's the same for plasma.
2007-09-18 18:22:53 · 5 answers · asked by sooner_touchdown 1 in Science & Mathematics ➔ Medicine
NO. Accutane (Isotretinoin) is 99.9% protein bound in human plasma.
So it won't be safe giving the possibility of transfusing it to a PREGNANT woman. It could present a small risk to the fetus if
transfused to a pregnant mother during the first trimester of pregnancy.
However, since the main concern is the risk over fetus of a pregnant woman, your being a plasma or blood donor may be considered IF you are specifically donating a blood to be transfused exclusively to a known person who will not be affected by the risk incurred by Accutane. That would include male blood recipient or a non-pregnant person. Accurate disclosure and proper arrangement may be done on this case, but that of course will depend on the doctor's judgement.
For becoming a usual donor where your plasma or blood goes to blood bank- YOU SHOULD NOT DONATE PLASMA. As recommended by its manufacturer, you may donate blood one month after discontinuation of the treatment.
2007-09-18 18:49:18 · answer #1 · answered by ♥ lani s 7 · 0⤊ 0⤋
No as it's still teratogenic. isotret is plasma protein bound so a large portion of it would be in the plasma. You can start giving blood 6-12 months after the end of treatment.
2007-09-18 20:46:15 · answer #2 · answered by Paula84 4 · 0⤊ 0⤋
No, it is bound to plasma proteins. It causes the worst type of birth defects.
The drug is more than 99.9% bound to plasma proteins.
See:
http://www.fda.gov/cder/foi/label/2005/018662s056lbl.pdf
The drug and its metabolites take a long while to be eliminated, in theory waiting at least 100 hours would rid the body of most of it, BUT considering the possible consequences, it would be best to wait several months, since fat soluble drugs can have a biphasic elimination, where for prolonged peroids trace amounts stored in the fat leach out into the blood.
2007-09-18 18:31:46 · answer #3 · answered by Anonymous · 1⤊ 0⤋
Besides being bound to plasma protiens, if it's on your blood, it's in your whole body.
Why not just wait untill your through taking the Acutane?
Also, ask a Dr. how much time to wait for your body to deplete it totally.
2007-09-18 18:52:19 · answer #4 · answered by Giddyup 4 · 0⤊ 0⤋
yes why not
2007-09-22 13:12:41 · answer #5 · answered by Anonymous · 0⤊ 0⤋