What is the inheritance pattern for PKU?

Answer 1

It's a recessive autosomal disease. People with PKU can't have gum with Phenyalanine. There is a 1/4 chance that a 2 heterozygous parents with the PKU allele will have offspring with the disease.

Answer 2

Pku Inheritance

Answer 3

Just so you know, the first person who answered your question is wrong. PKU is not a disease it is a metabolic genetic disorder. Again the first person is wrong because children and adults with PKU have to limit how much of the amino acid called Phenylalanine they take in weither or not it is the Phenylalanine in gum or other foods. The only reason that the first person who answered your question might think that is because alot of gums contain something called asparteme in it. 50% or more of Asparteme is made up of pure Phenylalanine. Phenylketonurics (People with PKU) have to restrict the amount of Phenylalanine they consume and asparteme has way to much Phenylalanine

Anyway, PKU is a recessive gene. So it all depends if a parent is a carrier (has one PKU gene and one normal gene), non carrier (doesn't have PKU and isn't a carrier) or a PKU parent. Here are the chances of having a child with PKU:

2 non carrier parents- 100% non carrier 0% carrier 0% PKU

1 carrier parent, 1 non carrier parent- 75% non carrier 25% carrier 0% PKU

2 carrier parents- 25% non carrier 50% carrier 25% PKU

2 PKU parents- 0% non carrier 0% carrier 100% PKU

1 non carrier parent 1 PKU parent- 0% non carrier 100% carrier 0% PKU

1 carrier parent 1 PKU parent- 0% non carrier 50% carrier 50% PKU

The only way a person would know if they are a carrier or not is if they were to get genotyped. Then you would basically be told what your DNA make up is. I hope this helps you!

Answer 4

This Site Might Help You.

RE:
What is the inheritance pattern for PKU?

Answer 5

It is simple recessive (not sex linked). So, if two parents, both carriers for phenylketonuria, were to have a child, the child would have a 1/4 chance of having PKU, and a 3/4 chance of being phenotypically normal. Genotypically, it would have a 1/4 chance of being homozygous negative, a 1/2 change of being a carrier, and again, a 1/4 chance of being affected (homozygous recessive).

Where P is normal, and p is PKU:

P p
P PP | Pp
p Pp | pp

Answer 6

Autosomal recessive.