Abnormal Biopsy?

Question

I went to the doctor a few weeks ago to have a mole removed and they performed a biopsy. I just got the results and they said that it is not cancer, but the biopsy was abnormal due to abnormal cell growth. I have to return to the doctor for a wider biopsy. Any idea what this could mean?

Answer 1

Thank you for posting this interesting question. By asking this, you showed interest in what's happening to your skin health and what to expect. So for your benefit and mine;: I decided to researched on it I wanted the studies to make my answer more factual. and well supported.


Moles are growths that occur when cells in the skin, called melanocytes, grow in a cluster with tissue surrounding them. Moles are usually pink, tan, brown or flesh-colored. Melanocytes are also spread evenly throughout the skin and produce the pigment that gives skin its natural color. When skin is exposed to the sun, melanocytes produce more pigment, causing the skin to tan, or darken.


Dysplastic nevus or nevi( plural) are unusual (or atypical) moles that looks different from an ordinary mole. The medical
Doctors believe that dysplastic nevi are more likely than ordinary moles to develop into a type of skin cancer called melanoma Doctors believe that dysplastic nevi are more likely than ordinary moles to develop into a type of skin cancer called melanoma.


Melanoma is a type of skin cancer — one of the most serious types because advanced melanomas have the ability to spread to other parts of the body. (Melanoma can also develop in the eye, called intraocular melanoma, or rarely in other parts of the body where pigment cells are found.)


Melanoma begins when melanocytes (pigment cells) gradually become more abnormal and divide without control or order. These cells can invade and destroy the normal cells around them. The abnormal cells form a growth of malignant tissue (a cancerous tumor) on the surface of the skin. Melanoma can begin either in an existing mole or as a new growth on the skin.


Biopsy can either be done by removal of the entire mole or a sample of tissue. . If possible, it is best to remove moles by an excisional biopsy, rather than a shave biopsy. It's a good sign that the biopsy of your excised mole resulted in the absence of melanoma cells. But the findings of abnormal cell growth means that there is proliferation or cell division or mutation involved. That's why your doctor wants a wider biopsy. ( Probably, your biopsy was done on a tissue sample only. ) done to further investigate this.


The following are criteria to denote any abnormal skin cells growth Early detection is the surest way to a cure.

Develop a regular routine to inspect your body for any skin changes. If any growth, mole, sore or skin discoloration appears suddenly or begins to change, see your dermatologist. Each of the skin cancers can be treated if detected early.


The ABC's of skin cancer: include any change or development in a mole or skin growth that should prompt you to see a dermatologist. These may include;

A- Asymmetry- You should notice the general look of your moles or growths, for example, if one half of the mole or growth does not match the other half.

B- Border Irregularity - If the edges of the growth are ragged, notched or blurred.

C- Color - The pigmentation of the growth is not uniform. Shades of tan, brown and black are present. Dashes of red, white and blue add to the mottled appearance.

D- Diameter - If the width is greater than 6 millimeters (about the size of a pencil eraser), it could be an indicator of an abnormal skin growth. Generally, any new mole growth should be a concern.


If melanoma is not found early, the cancer cells can spread through the bloodstream and lymphatic system to form tumors in other parts of the body. Melanoma is much harder to control when it has spread. The spread of cancer is called metastasis


The site below will educate you on the risk factors and prevention: Highlight: Avoid sun exposure esp from 10AM - 4PM. when the destructive UVB rays ( carcinogenic) are prominent. UVA rays promotes the effects of UVB rays. SPF only indicate the duration of the protection time. not the strength. The best sunscreens and sunblocks are the ones with zinc oxide as its main ingredients.

http://www.medem.com/search/article_display.cfm?path=n:&mstr=/ZZZI4E6E38C.html&soc=JAMA/Archives&srch_typ=NAV_SERCH


You might also be interested to go to the below link on this :
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A 393-amino-acid protein designated p53 -- "p" for protein and "53" for its molecular weight -- has been named Molecule of the Year by the editor's of the journal Science.

This protein is a part of a fundamental pathway in human cell growth. It's transcriptor (reading) factor for DNA mutations. or cell growth.and proliferation. It suppresses or blocks abnormal cell proliferation. Thereby represents an important mechanism for protection against cancer. It also appears to be involved in programmed cell death, or apoptosis.


However, when a mutation in the p53 gene results in the substitution of one amino acid for another, p53 loses its ability to block abnormal cell growth. Indeed, some mutations produce a p53 molecule that actually stimulates cell division or transformation and promotes cancer.


Almost 50% of human cancers contain a p53 mutation -- including cancers of the breast, cervix, colon, lung, liver, prostate, bladder, and skin -- and these cancers are more aggressive, more apt to metastasize, and more often fatal.


Researchers are looking for ways to use it for the diagnosis, prevention, and cure of cancers associated with p53 mutations.

http://agham.asti.dost.gov.ph/3rd/inside/extras/p53_mole.html

Answer 2

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RE:
Abnormal Biopsy?
I went to the doctor a few weeks ago to have a mole removed and they performed a biopsy. I just got the results and they said that it is not cancer, but the biopsy was abnormal due to abnormal cell growth. I have to return to the doctor for a wider biopsy. Any idea what this could mean?

Answer 3

Atypical Mole Biopsy

Answer 4

Hi,..... I had the same thing TWICE! They did another pap 6 months later after doing the whole 45 min biopsy.. which is very uncomfortable to have your legs and vag vag for the world to see.. but anyways.. EVERYTHING WAS FINE.. sometimes its a hormone imbalance and causes an over growth in cells.. Honestly unless the doc comes back and says yes you have it 100% certain dont give it too much thought.. listen... if it was something super serious they wouldnt have told you to come back in 3 months!

Answer 5

They aren't many proven answers on the market, and even those who are typically applied do not provide lasting results. As an example, physicians usually recommend medical techniques to remove moles and warts but with this specific manual, Moles, Warts and Skin Tags Removal from here you will see out that's yet another way https://tr.im/5GT3g
When you can use Moles, Warts and Skin Tags Removal system you will feel therefore definitely better about yourself.  You will be able to head out again, without the distress at all because this technique performs on every form of mole, epidermis tag, and wart.  It's actually secure to utilize for genital warts. 
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Answer 6

It means it has the potential to become cancerous. They want to make sure they get all of the cells out so it doesn't have the opportunity to regrow and develop into something more serious. My husband had the same thing happen to him.

Don't worry about it. Just make sure you get it taken care of.