What is the reason behind a decrease in calcium serum levels in a case of acute pancreatitis?

Answer 1

Hypercalcemia or high calcium levels produces AP through calcium-mediated activation of trypsinogen and subsequent glandular autodigestion. Hypercalcemia-associated AP may occur in the setting of primary and secondary hyperparathyroidism, malignancy, and metabolic bone disease. In recent years, numerous genetic mutations have been associated with the development of acute and chronic pancreatitis.


That's why calcium level is lower than 8 mg/dL because of the underproduction of the pancreatic enzyme of trypsinogen.