Oxidation is regarded as being one of the number one killers in our society today because our bodies react with oxygen to create harmful free radicals. Why is it then that certain "diet pills" regard fatty acid oxidation as being a good thing?
Example: Stearoylethanolamide (SEA) has been shown to decrease food intake independent of PPAR and without changing hematochemical parameters such as glucose and triglyceride levels or leptin (a hormone involved with satiety) expression.
The appetite decreasing effect of SEA was associated with a reduction in liver stearoyl-CoA desaturase-1 (SCD-1) mRNA expression. SCD-1 is the rate-limiting enzyme in the biosynthesis of monounsaturated fats and its reduction is believed to lead to increased "fatty acid oxidation" and decreased lipogenesis in skeletal muscle and the liver.
2007-08-25
19:30:19
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3 answers
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Anonymous
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Health
➔ Diet & Fitness