What are the four mechanisms on how steroids produce osteoporosis?

Answer 1

>>Steroids decrease the amount of calcium absorbed by the intestine and increases calcium excretion through the kidneys.

>>Those two factors combine to produce a decline in the circulating ionized calcium concentration.

>>That triggers the parathyroid glands to increase the secretion of parathyroid hormone (PTH).

>>Elevated PTH levels result to increased bone breakdown, as the body attempts to rectify low circulating calcium levels by releasing calcium from the bones into the blood.

==The result at the end of above mechanisms is OSTEOPOROSIS.