Is mom or dad responsible, genetically (or age), for a down syndrome child?

Question

This is totally hypothetical. I just know that as a woman gets older her chances of having a baby with Downs grows. Is this the same situation for a man? IE: if the woman is in her late 20's buth the man in in his mid 40's what is their chance of having a child with Downs? Thanks

Answer 1

"Most cases of Down syndrome aren't inherited. They're caused by a mistake in cell division during the development of the egg, sperm or embryo." The risk of having a baby with Down Syndrome does increase with the mother's age. While the risk is about 1 in 385 for women age 35 and 1 in 30 for mothers age 45, most babies born with Down Syndrome are actually born to women under 35 because this age group has more babies. More than 90 percent of cases of Down syndrome are caused by trisomy 21. This form of Down syndrome is caused by abnormal cell division during the development of the sperm cell or the egg cell. Early studies of a man's age and the risk for Down Syndrome seem to show an older father and an older mother are more at risk than an older father and a younger mother. However, these are preliminary studies.

Answer 2

Its an interesting question and I have researched the age/risks of Downs Syndrome and Autism because my Husband is in his early 40s while I'm in my early 30s. In relation to Downs syndrome I have only found that a womans age "matters" because as the eggs mature (you are born with a certain number of eggs and don't make any more) they become "brittle" this is also why older women have a harder time conceiving. Whereas Mens sperm is constantly regenerating, thus they can make babies until they die. There also have not been as many studies on paternal ages as there have on maternal ages.

Answer 3

on a similar time as the possibility for having a baby with DS a great deal will strengthen with age, age isn't the only component. Downs syndrome is led to whilst there are 3 copies of chromosome 21 (there would desire to in ordinary terms be 2... one from father, one from mom)... Downs syndrome is a genetic ailment that occurs (lots of the time) with an blunders in egg formation (meiosis). The scientific call is a "non-disjunction blunders". ninety 5% of all cases of Downs Syndrome occurs whilst a sperm (containing one chromosome 21) fertilizes an egg that has one greater replica - making 3 entire copies in the fertilized egg.

Answer 4

I don't think the man has much to do with it, but it's not really either parents "fault"

Yes, as a woman ages the odds of a downs baby goes up, but so do the chances of having identical twins.

Personally I think it has to do with the process of the DNA merging somehow. But, what do I know, I'm not a doctor.

Answer 5

there is a slightly higher risk with an older father, but its more common in older mothers.

Answer 6

seems like i read awhile back that it is almost exclusively passed on through the mother