Is there any advanced treatment for fibrinogen 1 deficiency?

Question

Is there any manual and advanced treatment (drugs) for fibrinogen 1 deficiency? Is fibrinogen 1 deficiency kind of heamophilia? Is there any drugs which can stop the bleeding?

Answer 1

To control or prevent bleeding, all that’s required is to increase the fibrinogen level in the blood with blood products or substitutes. The aim of the treatment is to increase the fibrinogen level to 1 g/L when there is minor bleeding, and 2 g/L for serious bleeding or for surgery.

For the mean time,cryoprecipitate is the treatment of choice in the United States. Fresh Frozen Plasma may be given, but cryoprecipitate is used more often to avoid volume overload. There are no Factor I concentrates available for use in the U.S. but there are three fibrinogen concentrates available in Europe and Japan however there are some reports of adverse reactions with use of these concentrates. There are current clinical trials ongoing and one is the trial on the safety of "Human Fibrinogen". So hang on in there for possible advance treatments of fibrinogen defeciency.

No it is not hemophilia. There are different blood factors and hemophilia is caused dy defeciency in either Factor VIII (Hemophilia A ) or Factor IX ( Hemophilia B). Factor 1 defeciency is fibrinogen defeciency.

Aminocaproic acid (Amicar) may be used to stop the bleeding. These are useful in conjunction with fibrinogen replacement for the treatment of mucosal bleeding, particularly bleeding involving the oronasopharynx. Inhibition of local fibrinolysis allows maintenance of the clot and decreases the frequency of rebleeding.