What are the causes of thrombocytopenia/low platelet count in dengue haemorrhagic fever?

Answer 1

Thrombocytopenia in Dengue Haemorhagic Fever can be explained by the following mechanisms:
>>Dengue virus induces bone marrow
suppression.
>>Dengue virus can bind to human platelets
in presence of virus specific antibody
and immune mediated clearance of
platelets.
>>Spontaneous aggregation of platelets to
vascular endothelial cell pre-infected by
virus inducing aggregation, lysis and
platelet destruction.
>> Anti-platelet antibodies generated after
dengue virus infection causes destruction
of platelets.

Answer 2

Dengue is a mosquito-borne disease caused by a flavivirus. Dengue fever usually results in the abrupt onset of high fever, headache, myalgias, arthralgias, lymphadenopathy, and a rash that appears with a 2nd temperature rise after an afebrile period. Respiratory symptoms, such as cough, sore throat, and rhinorrhea, can occur. Dengue can also cause potentially fatal hemorrhagic fever with bleeding tendency and shock. Diagnosis involves PCR and serologic testing. Treatment is symptomatic, including meticulously adjusted intravascular volume replacement.
Dengue fever can cause thrombocytopenia by direct infection of bone marrow megakaryocytes as well as immunological shortened platelet survival.
Please see the web pages for more details on Dengue hemorrhagic fever.

Answer 3

Causes Of Thrombocytopenia

Answer 4

The virus directly destroys platelets