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in humans, what is the possibility of getting the same bone marrow, with using a closely related person (sister...etc)

2007-06-22 15:11:07 · 2 answers · asked by Anonymous in Science & Mathematics Medicine

i meant without using closely related...

2007-06-22 15:13:51 · update #1

2 answers

To have compatible bone marrow doesn't mean that you have the same type. Thare are only two types of bone marrow- the red and the yellow. The main factor that matters is the thing called " human leukocyte antigen" (HLA) which is the determinant if bone marrow of different individuals do match. It is termed as major histocompatibility complex (MHC). This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and many other genes. Aside from the genes encoding the 6 major antigens, there is a large number of other genes, many involved in immune function located on the HLA complex. Diversity of HLA in human population is one aspect of disease defense, and, as a result, the chance of two unrelated individuals having identical HLA molecules on all loci is very low, except for non-identical siblings, which have a 25% chance of being HLA-identical, or identical twins, which have an almost 100% chance of being HLA-identical.

2007-06-22 18:59:56 · answer #1 · answered by ♥ lani s 7 · 0 0

There are many factors in bone marrow cross matching, which is what you are asking about. Not only blood type, but gender, and race play a part. That is because certain blood and antibody factors are found in different populations (Asians versus Africans, say)
The closest match to a person who needed bone marrow would be an identical twin. Siblings, that is brothers and sisters have only about 25% of their genes in common, but that would be the next likely close match. But still, that is a closer match than a parent (which may fewer genes in common than a sibling) That is because of a phenomena called cross-linking in genes.
There are two types of bone marrow: red marrow (also known as myeloid tissue) and yellow marrow. Red blood cells, platelets and most white blood cells arise in red marrow; some white blood cells develop in yellow marrow. The color of yellow marrow is due to the much higher number of fat cells. Both types of bone marrow contain numerous blood vessels and capillaries.

At birth, all bone marrow is red. With age, more and more of it is converted to the yellow type. Adults have on average about 2.6kg (5.7lbs) of bone marrow, with about half of it being red. Red marrow is found mainly in the flat bones such as hip bone, breast bone, skull, ribs, vertebrae and shoulder blades, and in the cancellous ("spongy") material at the proximal ends of the long bones femur and humerus. Yellow marrow is found in the hollow interior of the middle portion of long bones.
In cases of severe blood loss, the body can convert yellow marrow back to red marrow in order to increase blood cell production.

Here's a link on bone marrow transplantation: http://en.wikipedia.org/wiki/Hematopoietic_stem_cell_transplantation

2007-06-22 15:21:29 · answer #2 · answered by phantomlimb7 6 · 0 0

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