It depends on what you mean by "invented":
1) If you mean a conspiracy theory, in which there is no such a thing as a virus causing the Acquired Human Immunodeficiency Syndrome (AIDS), then the answer is "no", the virus does indeed exist. For about a decade, the pathogenic agent that caused AIDS was unknown. Many scientists thought it was caused by a toxin, or a genetic disease, or something else. The problem is that HIV has a very sensible structure, so it's very hard to reproduce in laboratory (which is, in most cases, the only way to confirm the presence of a virus in a host). Currently, not only the virus has been isolated, but different varieties have been found.
2) If you mean that somebody "built" it, then the answer is "maybe". "Maybe" because, although it's very hard to manipulate genetical material (DNA and RNA) with today's nanotechnology, it's not impossible. Currently, it's not possible to build a virus from zero, because we don't have many fundamental technology:
a) A virus must have a genetic material that the host cells can replicate. The current DNA/RNA sequence builders can only join some hundreds nucleotides (if you are lucky!), while the smallest virus has many thousands.
b) A virus must have a structure that allows it to "board" the host cells. It must chemically recognize the host cell's wall and attach to it (not only that, it must attach to a site where the virus can open a breach). After attaching, it must force its genetic material into the cell.
c) The genetic material must be recognized by the cell's internal transport mechanisms in such a way that it is carried to the ribosomal complex to be replicated (instead of being destroyed, as are all unrecognized DNA or RNA found loose inside the cell's cytoplasm). The genetic material must have the correct "access codes" that will misinstruct the ribosomes to replicate it...
There are so many details that, even if we had the technology to build a virus from scratch, it would still take a very long time to build one that could actually do anything, because it's not just a case of having the means to do it, but the knowledge of WHAT to do!
The problem is DNA has received a lot of attention lately, having been called "the molecule of life", but that couldn't be farther from the truth. Proteins are, in fact, the molecules of life. They had existed for millions of years (or maybe billions) before the first living organism developed a nucleic acid structure to store genetic data. Even today, there are some proteins that can replicate, without the need of genetic material. Likewise, we will be building "intelligent proteins" much before we start programming our own DNA. And, currently, we are so very far away from designing our own proteins...
There is an alternative, though, that has been used by many scientists: instead of building a virus from scratch, they change existing virii, forcing mutations or transmutations in them. There are many techniques to do that, but they basically mix "random" fragments of genetic material with a virus and inoculate it into test subjects. They wait and watch what the changed virus does. The fragments are, usually, not completely random, they take them from something that has a property of interest. For example, imagine a scientist wants to induce immunity against HIV using a harmless flu or cold virus. The HIV's genetic material is fragmented and the fragments inserted into the harmless receptor virus. The resulting virus is injected in mice and, after some days, they run blood tests on them, looking for HIV antibodies. The positives are separated and their virii replicated. That way, the random fragments that could induce HIV resistance are selected. Of course, that is an expensive and slow technique, but it's basically the only available (for practical use, I mean). It is also very dangerous, because you can cause not only "good mutations", but also "bad" ones (for example, a cold virus could start affecting the immunologic system, instead of the respiratory tract, making it a new AIDS virus, transmissible through the air!)
Now, answering the question (finally), HIV virus could have been artificially changed from another virus to become the AIDS virus, but that's not very likely. The origin of the HIV is most probably from a mutation from a monkey virus. Primates (including humans) share most of the same DNA code, so it's not that hard for a virus to "jump" from one species to another. The problem is, when a virus "jumps" species, they usually come very virulent. The human herpes virus, for example, is lethal to small monkeys (it's FORBIDDEN to herpes-positive people to treat monkeys in zoo parks).
Another example, the Ebola virus, it was so deadly because it was derived from a plant virus (plants have millions of virus, we just don't care enough to really research on them, as long as they don't cause economic losses). The plant virii are so different that, when they change enough to infect an animal, usually it dies so fast that they cannot spread to other hosts. The Ebola probably infected another animal before jumping to the humans, having enough time to adapt and to disseminate.
Anyway, HIV most likely came from other primates (cats are also carriers of a virus very similar to HIV, so monkeys are not the only possibility, just the most likely), but that probably happened a long time ago, it's too adapted to the human species to be a recent mutation (that is, actually, the source of the urban legend that it was "invented", people say it's too "perfect" to be natural). There could have been a mutation that turned it into a lethal virus, otherwise it could go on unnoticed for decades. Another possibility is that it stayed in an isolated population, killing people young, but they ever died young there (poverty, wars, other diseases etc.), so no one noticed anything different, until european missionaries or tourists arrived and took the virus with them after sexual contacts with those people.
The natural and social explanations are much more likely than the conspiratory theories: we are very far from being able to produce such a deadly virus (not because we don't have the means, it's just that it would take so long, and so much money, and the people that make bioweapons are always so hasty...)
2007-06-01 16:40:06
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answer #5
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answered by Cyberknight 1
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