Does High Uric acid level bring knee pain ?

Answer 1

Sounds like you have Gout.

Answer 2

Yes. Its called gout, a form of arthritis caused by high levels of uric acid. See link.

Answer 3

Yes, it can affect the knee. Most commonly, high uric acid levels causes inflammation, and hence pain to the big toe or foot. But if your body cannot remove the uric acid, it gets deposited in tissues, like joint areas. High uric acid level can cause kidney damage when it gets deposited in the renal tissues.

Answer 4

The word is furosemide aka lasix. Take the meds as prescribed but be sure you eat foods high in potassium. Your uric acid and sodium levels will be fine so long as you watch your salt aka sodium intake. Your doc was aware of everything before he prescribed these meds for you so please take them like you are supposed to and get your blood pressure under control.

Answer 5

Uric acid (or urate) is an organic compound of carbon, nitrogen, oxygen and hydrogen
Excess serum accumulation of uric acid can lead to a type of arthritis known as gout.[6]

Elevated (serum uric acid) level (hyperuricemia) can result from high intake of purine-rich foods, high fructose intake (regardless of fructose's low Glycemic Index (GI) value) and/or impaired excretion by the kidneys. Saturation levels of uric acid in blood may result in one form of kidney stones when the urate crystallizes in the kidney. Some patients with gout eventually get uric kidney stones.

Gout can occur where serum uric acid levels are as low as 6 mg/dL (~357µmol/L), but an individual can have serum values as high as 9.5 mg/dL (~565µmol/L) and not have gout[7] (no abstract available; levels reported at[8]).


[edit] Lesch-Nyhan syndrome
Lesch-Nyhan syndrome is also associated with very high serum uric acid levels.[9]

Spasticity, involuntary movement and cognitive retardation as well as manifestations of gout are seen in cases of this syndrome.[10]


[edit] Cardiovascular disease
Although uric acid can act as an antioxidant, excess serum accumulation is implicated in cardiovascular disease[11]


[edit] Low Uric Acid

[edit] Multiple sclerosis
Lower serum values of uric acid have been associated with Multiple Sclerosis.[12] Multiple sclerosis (MS) patients have been found to have serum levels ~194µmol/L, with patients in relapse averaging ~160µmol/L and patients in remission averaging ~230µmol/L. Serum uric acid in healthy controls was ~290µmol/L.[13] (1mg/dL=59.48 µmol/L)[14]

A 1998 study completed a statistical analysis of 20 million patient records, comparing serum uric acid values in patients with gout and patients with multiple sclerosis. Almost no overlap between the groups was found.[15]

Uric acid has been successfully used in the treatment and prevention of the animal (murine) model of MS. A 2006 study found that elevation of serum uric acid values in multiple sclerosis patients, by oral supplementation with inosine, resulted in lower relapse rates, and no adverse effects.[16]


[edit] Oxidative Stress
Uric acid may be a marker of oxidative stress,[17] and may have a potential therapeutic role as an antioxidant (PMID 16375736). On the other hand, like other strong reducing substances such as ascorbate, uric acid can also act as a peroxidant,[18] particularly at elevated levels. Thus, it is unclear whether elevated levels of uric acid in diseases associated with oxidative stress such as stroke and atherosclerosis are a protective response or a primary cause.[19]

For example, some researchers propose that hyperuricemia-induced oxidative stress is a cause of Metabolic syndrome.[20][21] On the other hand, plasma uric acid levels correlate with longevity in primates and other mammals.[22] This is presumably a function of urate's antioxidant properties.


[edit] Sources of uric acid
In many instances, people have a high incidence of uric acid for hereditary reasons.


Diet may also be a factor.

Purines are found in high amounts in animal food products, especially internal organs.[23]

Examples of high purine sources include: sweetbreads, anchovies, sardines, liver, beef kidneys, brains, meat extracts (e.g Oxo, Bovril), herring, mackerel, scallops, game meats, and gravy.

A moderate amount of purine is also contained in beef, pork, poultry, fish and seafood, asparagus, cauliflower, spinach, mushrooms, green peas, lentils, dried peas, beans, oatmeal, wheat bran and wheat germ.[24]

Moderate intake of purine-containing food is not associated with an increased risk of gout.[25]


Serum uric acid can be elevated due to high fructose intake, reduced excretion by the kidneys, and or high intake of dietary purine.

Fructose can be found in processed foods and soda beverages - in some countries, in the form of high fructose corn syrup.