Is it possible to overdose on LSD?

Question

Is it possible to die from an overdose of LSD? Hurting yourself while under the psychosis state doesnt count.

Answer 1

Yes. The lethal dose of LSD that would kill 50% of average sized humans is estimated at about 12,000 micrograms, based on studies of animals.

The usual street dose is 50 - 150 micrograms, so you would need to take well over 100 doses to reach the lethal level.

Answer 2

Lsd Overdose

Answer 3

Overdose On Lsd

Answer 4

You had some good answers. I just want to add that people die from LSD not just from OD-ing, but from delusional, dangerous behavior after taking LSD. An LSD high is similar to psychosis, which results in people under the influence of LSD doing things like walking into traffic & trying to "fly" off bridges & buildings. They are generally disoriented and unable to appreciate the dangerousness of their actions. Also, people are often beaten & mugged and girls raped while they're "out of it" on an acid trip. As for Salvia, in California we've had many deaths due to ingesting dangerous amounts. Keep in mind, too, that these are hardly FDA approved medications for which each unit is guaranteed to contain the same dose of medication. With a tab of acid, or a bag of Salvia, you have no way to know how high a dose of the active ingredients you're going to end up with. Could be low, could be what you're expecting, and could be very potent & send you to the hospital (or morgue). No way to tell. Much better to leave that all that junk alone.

Answer 5

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Yes, as with everything. The popular conception of "overdose" is incorrect, an overdose is just an excessive or ill advised dose, that's it. The poster claiming folks have died in california is wrong. Salvia will not kill you. It is a kappa opioid agonist, and you'd have to take a ton for this pathway to negativly effect your health, its simply not an important physiological pathway for life functions. The kappa opioid pathway is in many respects a modulator of the mu opioid pathway associated w/ narcotics. The two are in some ways inversely related, so while mu can cause loss of sensation, depressed breathing and cognition, kappa will cause the opposites in many cases, and very generally. LSD is unlikely to kill a healthy person. Its effects include a vascoconstrictive effect similar to coffee, some SSRI's,or similar stimulants. If you take a ton this may get relevant to your cardiovascular health, acutely, but even huge doses are unlikely to effect you negativly besides psychological manifestations. As for the claim that people jump off buildings on LSD and whatnot, anything can hapen. But anyone whos tried it knows your not in a trance or whatever, the serotnoergic activity makes you much more acutely aware of what's going on. While you may be more prone to impulsivness, as most serotonergic drugs will cause this- like SSRI's, you are not likely to decide its a good idea to jump off a building. I'd like to see some stats as to how many documented cases these folks can link deaths to LSD and Salvia. The only thing they can likely find are disturbed individuals making bad choices, which is clearly not a physical manifestation of the drug. Their was a kid who killed himself about a month or two after mentioning salvia in his journal, and this somehow gets labled a salvia related death... crazy. So stay safe and dono't worry, but yes, it is possible to overdose on anything, coffee, LSD, Salvia, and alcohol. It's all relative.

Answer 6

Technically it may be possible..................but there are VERY few people in the world that would have access to the amount of LSD it would take.

There has never been a single human death ever reported that was attributed to an LSD overdose, however I believe there was a study done in which they used it to kill lab mice, and even an elephant.

Answer 7

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RE:
Is it possible to overdose on LSD?
Is it possible to die from an overdose of LSD? Hurting yourself while under the psychosis state doesnt count.

Answer 8

I've done over 1000 at once (thumbprint of needlepoint--do NOT try this, it took me months of puddling to be able to psychologically handle the dose) to no ill physical effect. The mental effect, on the other hand, was otherworldly and it took me well over a week to fully recover from--even though the "buzz" portion only lasted about 24hrs. It's practically impossible to physically OD (tens of thousands of hits) but at certain dosage levels the mental effect means you will never be the same. For those of us chosen for the experience the "never in the same way" almost always means in a good way--we were chosen for a reason. For others, pure crystal or puddling liquid could trigger severe underlying mental conditions like schizophrenia.

Answer 9

Just as an FYI: those of us who treated drug abusers in the 1970's well remember the patients with horrendous hallucinations and flashbacks long after they had taken their last dose of LSD. We remember the once intelligent college students who literally fried their brains. I didn't follow up any patients longer than two years, but I am certain that many had great difficulty returning to main stream society.

LSD works in microgram doses. One gram is less that one-thirtieth of an ounce. A microgram is one millionth of that! LSD is a terrible drug.

Answer 10

The lethal dose of LSD is estimated at 14,000 mcg when LSD itself causes the death. In order to OD you have to take extremely concentrated forms.

"In massive overdoses, respiratory arrest, coma, emesis, hyperthermia, autonomic instability, and bleeding disorders can occur." http://www.emedicine.com/ped/topic2809.htm

Usually deaths that occur due to LSD consumption occur because the hallucinations influence in unsafe behavior. In some cases suicides have occured as users attempted to escape the effects of the drug.